3.2.1.35: hyaluronoglucosaminidase
This is an abbreviated version!
For detailed information about hyaluronoglucosaminidase, go to the full flat file.
Word Map on EC 3.2.1.35
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3.2.1.35
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glycosaminoglycans
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proteoglycans
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hyaluronan
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cartilage
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collagen
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heparan
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hyaluronidases
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disaccharide
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oligosaccharide
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dermatan
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fibronectin
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chondrocytes
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heparitinase
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articular
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hyals
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alcian
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cspgs
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acrosomal
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chabc
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aggrecan
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4-sulfate
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tetrasaccharide
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35ssulfate
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cumulus
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mucopolysaccharides
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haase
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pericellular
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keratanase
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pellucida
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6-sulphate
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hexasaccharide
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transglycosylation
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diagnostics
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chlorate
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chondroitin-6-sulfate
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rhamm
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ha-binding
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monosulfated
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hexuronic
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cetylpyridinium
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d-glucuronic
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molecular biology
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acrosome-reacted
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iduronic
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biotechnology
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glca
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3hglucosamine
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pharmacology
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perineuronal
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analysis
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neurocan
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disulfated
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octasaccharide
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tgfbr3
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heparinum
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medicine
- 3.2.1.35
- glycosaminoglycans
- proteoglycans
- hyaluronan
- cartilage
- collagen
- heparan
- hyaluronidases
- disaccharide
- oligosaccharide
- dermatan
- fibronectin
- chondrocytes
- heparitinase
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articular
-
hyals
-
alcian
-
cspgs
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acrosomal
- chabc
- aggrecan
- 4-sulfate
- tetrasaccharide
-
35ssulfate
-
cumulus
-
mucopolysaccharides
- haase
-
pericellular
- keratanase
- pellucida
-
6-sulphate
- hexasaccharide
-
transglycosylation
- diagnostics
- chlorate
- chondroitin-6-sulfate
-
rhamm
-
ha-binding
-
monosulfated
-
hexuronic
-
cetylpyridinium
-
d-glucuronic
- molecular biology
-
acrosome-reacted
-
iduronic
- biotechnology
-
glca
-
3hglucosamine
- pharmacology
-
perineuronal
- analysis
- neurocan
- disulfated
- octasaccharide
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tgfbr3
- heparinum
- medicine
Reaction
Synonyms
BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1
ECTree
3.2.1.35 hyaluronoglucosaminidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.2.1.35 - hyaluronoglucosaminidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hyaluronan + H2O
tetrasaccharides units of hyaluronan
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absolutely specific for
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?
hyaluronate + H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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?
hyaluronic acid-rich cumulus matrix + H2O
?
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investment of oocyte during sperm invasion
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
highly specific substrate with 10fold higher activity compared to chondroitin 4-sulfate, chondroitin 6-sulfate, or dermatan
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-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
-
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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-
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?
hyaluronan + H2O
?
complete degradation, absolutely specific for
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?
hyaluronan + H2O
?
human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity
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?
hyaluronan + H2O
hyaluronan oligomers
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the enzyme is required for fertility facilitating the penetration of sperm through the cumulus mass in the ovum
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?
hyaluronic acid + H2O
?
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involved in inflammatory reactions, exists as inactive form activated by metal ions
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-
?
hyaluronic acid + H2O
?
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important in hyaluronate catabolism in the vitreous
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?
hyaluronic acid + H2O
?
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two isoforms necessary for penetration of extracellular vestments surrounding eggs prior fertilization
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?
hyaluronic acid + H2O
?
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endo-mucopolysaccharidase hydrolysing acid mucopolysaccharides from connective tissue and chondroitin-sulfate in cartilage
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-
?
additional information
?
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the enzyme is a major allergen of bee venom which can induce serious, occasionally fatal, systemic IgE-mediated anaphylactic reactions in humans
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?
additional information
?
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alternative splicing controls the cellular expression of enzymatically active hyaluronidase
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?
additional information
?
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alternative splicing controls the cellular expression of enzymatically active hyaluronidase
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?
additional information
?
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alternative splicing controls the cellular expression of enzymatically active hyaluronidase
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?
additional information
?
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increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer
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?
additional information
?
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increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer
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?
additional information
?
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increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer
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?
additional information
?
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HPH-20 or SPAM1, sperm adhesion molecule 1, is a bifunctional enzyme, which is also an adhesion molecule with binding properties to the cumulus mass surrounding the ovum
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?
additional information
?
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Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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?
additional information
?
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Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
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Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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-
?
additional information
?
-
Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
-
-
?
additional information
?
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Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
-
-
?
additional information
?
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Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 or hyaluronidase-2 suppresses tumour growth in vivo but not in vitro, HYAL2 inhibits experimental lung metastases in nu/nu mice
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 or hyaluronidase-2 suppresses tumour growth in vivo but not in vitro, HYAL2 inhibits experimental lung metastases in nu/nu mice
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 or hyaluronidase-2 suppresses tumour growth in vivo but not in vitro, HYAL2 inhibits experimental lung metastases in nu/nu mice
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 suppresses tumour growth in vivo but not in vitro
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 suppresses tumour growth in vivo but not in vitro
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?
additional information
?
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this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 suppresses tumour growth in vivo but not in vitro
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?
additional information
?
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CD44-mediated specific role of certain populations of testicular enzyme in the induction of angiogenesis
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?
additional information
?
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enzyme activity in serum from tumour-bearing mice, e.g. H460M or SA87 cell grafted mice, is increased, the level is corrsponding to the tumour mass, not in serum from CB193 cell grafted mice
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?
additional information
?
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isozyme NNH2 is nontoxic, but indirectly potentiates the hemorrhagic activity of hemorrhagic complex-I
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?
