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3.2.1.18: exo-alpha-sialidase

This is an abbreviated version!
For detailed information about exo-alpha-sialidase, go to the full flat file.

Word Map on EC 3.2.1.18

Reaction

colominic acid
+
H2O
=
sialic acid
 +
lactose

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.18 exo-alpha-sialidase

Storage Stability

Storage Stability on EC 3.2.1.18 - exo-alpha-sialidase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 0.1 M KCN, six months
-
-20°C, 1 week, 20% of initial activity remains, no loss in activity after 3 weeks when 5% albumin is added
-
-20°C, 10% glycerol, 1 mM DTT, 0.2 mM 2-deoxy-2,3-didehydro-N-acetylneuraminic acid at least two months
-
-20°C, freeze-dried, 2 months in 50 mM sodium acetate buffer, pH 5 or in 50 mM potassium buffer, pH 6.5
-
-20°C, one week, 20% loss in activity
-
-20°C, over 4 months in 10% glycerol
Macrobdella sp.
-
-20°C, over a year
-
-20°C, pellet no loss in activity up to a month
-
-20°C, purified enzyme, sodium acetate, pH 4.5, stable for 1 year
-
-20°C, several months
-
-20°C, two months
-
-70°C, 3 months
-
-70°C, after 48 h inactivated
-
-80°C, 3 weeks, 60% of initial activity remains
-
-80°C, one month
-
-80°C, stable for 1 year
-
-80°C, storage of liver over a year, no loss in activity
-
0°C, 8 h, totally inactivated
-
4°C, 0.1 M acetate buffer, pH 5
-
4°C, 2 days without any loss in activity
-
4°C, 24 h, 30 to 40% loss in activity
-
4°C, 3 weeks
-
4°C, 50% loss of activity after 24 h
-
4°C, loss in haemagglutinating activity but not neuraminidase activity
-
4°C, more than 2 months
-
4°C, more than two years in albumin
-
4°C, purified enzyme, sodium acetate, pH 4.5, stable for 2 months
-
4°C, some days
-