3.2.1.18: exo-alpha-sialidase

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For detailed information about exo-alpha-sialidase, go to the full flat file.

Reaction

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.18 exo-alpha-sialidase

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Results	in table
31	Activating Compound
107956	AA Sequence
30	Application
1	CAS Registry Number
68	Cloned(Commentary)
26	Crystallization (Commentary)
20027	Disease/ Diagnostics
3	Expression
33	General Information
15	General Stability
387	IC50 Value
688	Inhibitors
29	kcat/KM [mM/s]
94	Ki Value [mM]
223	KM Value [mM]
107	Localization
87	Metals/Ions
95	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
450	Organism
3	Pathway
605	PDB ID
114	pH Optimum
26	pH Range
6	pH Stability
1	pI Value
31	Posttranslational Modification
221	Protein Variants
101	Purification (Commentary)
24	Reaction
1	Reaction Type
387	Reference
128	Source Tissue
69	Specific Activity [micromol/min/mg]
31	Storage Stability
755	Substrates and Products (Substrate)
86	Subunits
437	Synonyms
1	Systematic Name
63	Temperature Optimum [°C]
10	Temperature Range [°C]
22	Temperature Stability [°C]
36	Turnover Number [1/s]

Expression

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Expression on EC 3.2.1.18 - exo-alpha-sialidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

enzyme activity is rapidly increased in response to neural excitation

Rattus norvegicus

-

750993

the enzyme activity is increased in serum of prostate cancer patients

Homo sapiens

-

750221

the enzyme is upregulated at late developmental stage in embryo

Oryzias latipes

L0N7M7

729760