3.2.1.18: exo-alpha-sialidase

This is an abbreviated version!
For detailed information about exo-alpha-sialidase, go to the full flat file.

Reaction

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.18 exo-alpha-sialidase

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Results	in table
31	Activating Compound
107956	AA Sequence
30	Application
1	CAS Registry Number
68	Cloned(Commentary)
26	Crystallization (Commentary)
20027	Disease/ Diagnostics
3	Expression
33	General Information
15	General Stability
387	IC50 Value
688	Inhibitors
29	kcat/KM [mM/s]
94	Ki Value [mM]
223	KM Value [mM]
107	Localization
87	Metals/Ions
95	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
450	Organism
3	Pathway
605	PDB ID
114	pH Optimum
26	pH Range
6	pH Stability
1	pI Value
31	Posttranslational Modification
221	Protein Variants
101	Purification (Commentary)
24	Reaction
1	Reaction Type
387	Reference
128	Source Tissue
69	Specific Activity [micromol/min/mg]
31	Storage Stability
755	Substrates and Products (Substrate)
86	Subunits
437	Synonyms
1	Systematic Name
63	Temperature Optimum [°C]
10	Temperature Range [°C]
22	Temperature Stability [°C]
36	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.2.1.18 - exo-alpha-sialidase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

330 - 47700

4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid

4 entries

0.031 - 74200

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

14 entries

144

4-methylumbelliferyl D-N-acetylneuraminyl-alpha-(2->3)-D-galactopyranoside

Aspergillus fumigatus

-

pH 3.5, 37°C

717646

4857.3

4-methylumbelliferyl N-acetyl-alpha-D-neuraminic acid

Bacteroides fragilis

Q5L868

at pH 6.5 and 50°C

749667

729.2

4-nitrophenyl alpha-D-N-acetylneuraminic acid

Bacteroides thetaiotaomicron

Q8AAK9

pH 7.0 and 37°C

729295

8 - 8900

8-fluoromethylumbelliferyl alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside

4 entries

541.2

colominic acid

Bacteroides thetaiotaomicron

Q8AAK9

pH 7.0 and 37°C

729295

438

sialic acid

Bacteroides fragilis

Q5L868

at pH 6.5 and 50°C

749667

213.3

sialyl-alpha-2,3-lactose

Bacteroides thetaiotaomicron

Q8AAK9

pH 7.0 and 37°C

729295

328.6

sialyl-alpha-2,6-lactose

Bacteroides thetaiotaomicron

Q8AAK9

pH 7.0 and 37°C

729295

330

4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme R71L, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

11600

4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme D84A, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

26800

4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme Y358H, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

47700

4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid

Aspergillus fumigatus

Q4WQS0

wild type enzyme, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

0.031

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

mutant enzyme H275Y/S247N, at 37°C, pH not specified in the publication

752324

0.035

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

mutant enzyme H275Y/I223V, at 37°C, pH not specified in the publication

752324

0.048

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

mutant enzyme H275Y, at 37°C, pH not specified in the publication

752324

0.16

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

mutant enzyme S247N, at 37°C, pH not specified in the publication

752324

0.51

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

mutant enzyme I223V, at 37°C, pH not specified in the publication

752324

0.82

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C3W6G3

wild type enzyme, at 37°C, pH not specified in the publication

752324

916.9

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Bacteroides thetaiotaomicron

Q8AAK9

pH 7.0 and 37°C

729295

1025

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H1N1

C7FH46

at pH 5.5 and 37°C

751926

1679

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

influenza A virus H5N1

A5Z227

at pH 5.5 and 37°C

751926

14500

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme Y358H, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

19000

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme D84A, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

22300

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Aspergillus fumigatus

-

pH 3.5, 37°C

717646

53500

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Aspergillus fumigatus

Q4WQS0

wild type enzyme, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

74200

4-methylumbelliferyl alpha-D-N-acetylneuraminic acid

Aspergillus fumigatus

Q4WQS0

mutant enzyme R71L, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

8

8-fluoromethylumbelliferyl alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside

Aspergillus fumigatus

Q4WQS0

wild type enzyme, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

200

8-fluoromethylumbelliferyl alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside

Aspergillus fumigatus

Q4WQS0

mutant enzyme D84A, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

1620

8-fluoromethylumbelliferyl alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside

Aspergillus fumigatus

Q4WQS0

mutant enzyme R71L, pH 5.2, 16 mM sodium tartrate, at 37°C

729246

8900

8-fluoromethylumbelliferyl alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside

Aspergillus fumigatus

Q4WQS0

mutant enzyme Y358H, pH 5.2, 16 mM sodium tartrate, at 37°C

729246