3.2.1.143: poly(ADP-ribose) glycohydrolase

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For detailed information about poly(ADP-ribose) glycohydrolase, go to the full flat file.

Word Map on EC 3.2.1.143

3.2.1.143

polyadp-ribose

polyadp-ribosylation

parp-1

polymerase-1

adp-ribosylation

genotoxic

parylation

gallotannins

analysis

drug development

parthanatos

automodification

adp-ribosylhydrolase

pharmacology

padpr

olaparib

molecular biology

aif

medicine

Reaction

Synonyms

ADP-ribose glycohydrolase, ADP-ribosyl-acceptor hydrolase 3, ADPRHL2, ARH3, DrPARG, FOXG_05947, Genbank AB019366-derived protein GI 6518480, Genbank U78975-derived protein GI 2062407, glycohydrolase, poly(adenosine diphosphoribose), glycohydrolase, poly(adenosine diphosphoribose) (cattle clone 4/5), glycohydrolase, poly(adenosine diphosphoribose) (Rattus norvegicus strain BUF gene Parg), PAR glycohydrolase, PAR glyco�hydrolase, PARG, PARG1, PARG110, PARG111, PARG59, poly (ADP-ribose) glycohydrolase, poly(adenosine diphosphoribose) glycohydrolase, poly(adenosine diphosphoribose) glycosidase, poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31860), poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31870), poly(ADP-ribose) glycohydrolase (cattly clone 4/5), poly(ADP-ribose) glycohydrolase 1, poly(ADP-ribose)glycohydrolase, poly(ADP-ribosyl) glycohydrolase, poly-ADP-glycohydrolase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.143 poly(ADP-ribose) glycohydrolase

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Results	in table
20	Activating Compound
4069	AA Sequence
16	Application
5	CAS Registry Number
21	Cloned(Commentary)
10	Crystallization (Commentary)
178	Disease/ Diagnostics
11	Expression
91	General Information
1	General Stability
58	IC50 Value
317	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
20	KM Value [mM]
49	Localization
13	Metals/Ions
23	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
101	Organism
85	PDB ID
17	pH Optimum
4	pH Range
2	pH Stability
1	Posttranslational Modification
124	Protein Variants
19	Purification (Commentary)
16	Reaction
4	Reaction Type
99	Reference
84	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
113	Substrates and Products (Substrate)
22	Subunits
123	Synonyms
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
4	Turnover Number [1/s]

Purification

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Purification on EC 3.2.1.143 - poly(ADP-ribose) glycohydrolase

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4 entries

4 poly(ADP-ribose) glycohydrolase isoforms: G1, G2, G3, G4

cytoplasmic enzyme

Ni-NTA column chromatography

partial

poly(ADP-ribose) glycohydrolase II

Homo sapiens

208527

recombinant C-terminally His-tagged hPARG from Escherichia coli BL21(DE3) Gold by nickel affinity chromatography and gel filtration

Homo sapiens

Q86W56

752468

recombinant His-tagged wild-type and selenomethionine-labeled enzymes from Escherichia coli strain Rosetta (DE3) by nickel affinity chromatography and gel filtration

Tetrahymena thermophila

I6L8L8

732568

recombinant His-tagged wild-type enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, tag cleavage through rhinovirus 3C (HRV 3C) protease, anion exchange chromatography, gel filtration, and ultrafiltration, recombinant GST-tagged mutant enzymes by glutathione affinity chromatography

Homo sapiens

Q9NX46

754168

recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography

Fusarium oxysporum f. sp. lycopersici

A0A0D2XPQ9

752519

recombinant His6-tagged truncated enzyme, native and selenomethionine-labeled, from Escherichia coli strain BL21 by nickel affinity and heparin affinity chromatography, and gel filtration

Rattus norvegicus

Q9QYM2

732567

recombinant human PARG catalytic domain (residues 448-976) from Escherichia coli strain Rosetta (DE3) by nickel affinity chromatography, heparin chromatography, and gel filtration, recombinant His-tagged full-length wild-type and mutant D314E enzymes from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, tag cleavage through PreScission protease, and gel filtration, followed by ultrafiltration

Homo sapiens

Q9NX46

754165

recombinant N-terminally, TEV protease-cleavable His6-tagged wild-type and mutant enzymes, and selenomethionine-labeled enzyme from Escherichia coli strains BL21 (DE3) GOLD and B834 (DE3) by nickel affinity chromatography and gel filtration

Homo sapiens

Q86W56

732714

recombinant wild-type and mutant enzymes

Deinococcus radiodurans

Q9RZM4

754824

Talon immobilized metal affinity resin column chromatography and glutathione-Sepharose column chromatography

Homo sapiens

Q86W56

716831