Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP-ribose | inhibits poly(ADP-ribose) glycohydrolase II more strongly than poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
cAMP | inhibits poly(ADP-ribose) glycohydrolase II more strongly than poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
KCl | 100 mM, 50% inhibition, poly(ADP-ribose) glycohydrolase II | Cavia porcellus | |
NaCl | 50-100 mM, poly(ADP-ribose) glycohydrolase II | Cavia porcellus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00058 | - |
(ADP-ribose)n | average chain length n = 27, poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
0.0011 | - |
(ADP-ribose)n | average chain length n = 21, poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
0.002 | - |
(ADP-ribose)n | average chain length n = 15, poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
0.0031 | - |
(ADP-ribose)n | average chain length n = 27, poly(ADP-ribose) glycohydrolase II | Cavia porcellus | |
0.004 | - |
(ADP-ribose)n | average chain length n = 21, poly(ADP-ribose) glycohydrolase II | Cavia porcellus | |
0.0045 | - |
(ADP-ribose)n | average chain length n = 6.7, poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
0.0048 | - |
(ADP-ribose)n | average chain length n = 15, poly(ADP-ribose) glycohydrolase II | Cavia porcellus | |
0.0066 | - |
(ADP-ribose)n | average chain length n = 6.7, poly(ADP-ribose) glycohydrolase II | Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | poly(ADP-ribose) glycohydrolase II | Cavia porcellus | 5737 | - |
nucleus | poly(ADP-ribose) glycohydrolase I | Cavia porcellus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | 50-100 mM, stimulates poly(ADP-ribose) glycohydrolase I | Cavia porcellus | |
NaCl | 50-100 mM, stimulates poly(ADP-ribose) glycohydrolase I | Cavia porcellus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57000 | - |
poly(ADP-ribose) glycohydrolase II, gel filtration | Cavia porcellus |
59500 | - |
1 * 59500, poly(ADP-ribose) glycohydrolase II, SDS-PAGE | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
cytoplasmic enzyme | Cavia porcellus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
13.4 | - |
poly(ADP-ribose) glycohydrolase II | Cavia porcellus |
Storage Stability | Organism |
---|---|
-20°C, stable for at least 6 months | Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-ribose)n + H2O | - |
Cavia porcellus | ADP-ribose | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 59500, poly(ADP-ribose) glycohydrolase II, SDS-PAGE | Cavia porcellus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
poly(ADP-ribose) glycohydrolase I | Cavia porcellus |
7.4 | - |
poly(ADP-ribose) glycohydrolase II | Cavia porcellus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | optimal stability | Cavia porcellus |