3.2.1.143: poly(ADP-ribose) glycohydrolase
This is an abbreviated version!
For detailed information about poly(ADP-ribose) glycohydrolase, go to the full flat file.
Word Map on EC 3.2.1.143
-
3.2.1.143
-
polyadp-ribose
-
polyadp-ribosylation
-
parp-1
-
polymerase-1
-
adp-ribosylation
-
genotoxic
-
parylation
-
gallotannins
-
analysis
-
drug development
-
parthanatos
-
automodification
-
adp-ribosylhydrolase
-
pharmacology
-
padpr
-
olaparib
-
molecular biology
-
aif
-
medicine
- 3.2.1.143
-
polyadp-ribose
-
polyadp-ribosylation
- parp-1
- polymerase-1
-
adp-ribosylation
-
genotoxic
-
parylation
- gallotannins
- analysis
- drug development
-
parthanatos
-
automodification
-
adp-ribosylhydrolase
- pharmacology
-
padpr
- olaparib
- molecular biology
- aif
- medicine
Reaction
Synonyms
ADP-ribose glycohydrolase, ADP-ribosyl-acceptor hydrolase 3, ADPRHL2, ARH3, DrPARG, FOXG_05947, Genbank AB019366-derived protein GI 6518480, Genbank U78975-derived protein GI 2062407, glycohydrolase, poly(adenosine diphosphoribose), glycohydrolase, poly(adenosine diphosphoribose) (cattle clone 4/5), glycohydrolase, poly(adenosine diphosphoribose) (Rattus norvegicus strain BUF gene Parg), PAR glycohydrolase, PAR glycohydrolase, PARG, PARG1, PARG110, PARG111, PARG59, poly (ADP-ribose) glycohydrolase, poly(adenosine diphosphoribose) glycohydrolase, poly(adenosine diphosphoribose) glycosidase, poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31860), poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31870), poly(ADP-ribose) glycohydrolase (cattly clone 4/5), poly(ADP-ribose) glycohydrolase 1, poly(ADP-ribose)glycohydrolase, poly(ADP-ribosyl) glycohydrolase, poly-ADP-glycohydrolase
ECTree
3.2.1.143 poly(ADP-ribose) glycohydrolaseAdvanced search results
results (
results (Reference
top
Reference on EC 3.2.1.143 - poly(ADP-ribose) glycohydrolase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lin, W.; Ame, J.C.; Aboul-Ela, N.; Jacobson, E.L.; Jacobson, M.K.
Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase
J. Biol. Chem.
272
11895-11901
1997
Bos taurus (O02776), Bos taurus
Maruta, H.; Inageda, K.; Aoki, T.; Nishina, H.; Tanuma, S.I.
Characterization of two forms of poly(ADP-ribose) glycohydrolase in guniea pig liver
Biochemistry
30
5907-5912
1991
Cavia porcellus
Brochu, G.; Shah, G.M.; Poirier, G.G.
Purification of poly(ADP-ribose) glycohydrolase detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis
Anal. Biochem.
218
265-272
1994
Bos taurus
Sugimura, T.; Yamada, M.; Miwa, M.; Matsushima, T.; Hidaka, T.; Nagao, M.; Inui, N.; Takayama, S.
Properties of poly(adenosine diphosphate ribose) polymerase, poly(adenosine diphosphate ribose) glycohydrolase and poly(adenosine diphosphate ribose)
Biochem. Soc. Trans.
1
642-644
1973
Bos taurus
-
Pacheco-Rodriguez, G.; Alvarez-Gonzalez, R.
Measurement of poly(ADP-ribose) glycohydrolase activity by high resolution polyacrylamide gel electrophoresis: specific inhibition by histones and nuclear matrix proteins
Mol. Cell. Biochem.
193
13-18
1999
Rattus norvegicus
Concha, I.I.; Koide, S.S.; Burzio, L.O.
Characteristics of the inhibition of poly(ADP-ribose) glycohydrolase by homopolypurines
Biochem. Int.
16
397-403
1988
Rattus norvegicus
Tanuma, S.i.; Sakagami, H.; Endo, H.
Inhibitory effect of tannin on poly(ADP-rinbose) glycohydrolase
Biochem. Int.
18
701-708
1989
Homo sapiens
Miwa, M.; Sugimura, T.
Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract
J. Biol. Chem.
246
6362-6364
1971
Bos taurus
Miwa, M.; Tanaka, M.; Matsushima, T.; Sugimura, T.
Purification and properties of a glycohydrolase from calf thymus splitting ribose-ribose linkages of poly(adenosine diphosphate ribose)
J. Biol. Chem.
249
3475-3482
1974
Bos taurus
Hatakeyama, K.; Nemoto, Y.; Ueda, K.; Hayaishi, O.
Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose)
J. Biol. Chem.
261
14902-14911
1986
Bos taurus
Tanuma, S.i.; Kawashima, K.; Endo, H.
Purification and properties of an (ADP-ribose)n glycohydrolase from guinea pig liver nuclei
J. Biol. Chem.
261
965-969
1986
Cavia porcellus
Tanuma, S.i.; Endo, H.
Purification and characterization of an (ADP-ribose)n glycohydrolase from human erythrocytes
Eur. J. Biochem.
191
57-63
1990
Homo sapiens
Tavassoli, M.; Tavassoli, M.H.; Shall, S.
Isolation and purification of poly(ADP-ribose) glycohydrolase from pig thymus
Eur. J. Biochem.
135
449-455
1983
Sus scrofa
Slama, J.T.; Aboul-Ela, N.; Jacobson, M.K.
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
J. Med. Chem.
38
4332-4336
1995
Bos taurus
Abe, H.; Tanuma, S.
Properties of poly(ADP-ribose) glycohydrolase purified from pig testis nuclei
Arch. Biochem. Biophys.
336
139-146
1996
Sus scrofa
Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M.
Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells
Biochem. Biophys. Res. Commun.
307
915-921
2003
Homo sapiens
Patel, C.N.; Koh, D.W.; Jacobson, M.K.; Oliveira, M.A.
Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain
Biochem. J.
388
493-500
2005
Bos taurus (O02776), Bos taurus
Gagne, J.P.; Bonicalzi, M.E.; Gagne, P.; Ouellet, M.E.; Hendzel, M.J.; Poirier, G.G.
Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles
Biochem. J.
392
499-509
2005
Homo sapiens
Blenn, C.; Althaus, F.R.; Malanga, M.
Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death
Biochem. J.
396
419-429
2006
Mus musculus
Uchiumi, F.; Ikeda, D.; Tanuma, S.
Changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases during the differentiation of human promyelocytic leukemia cell line HL-60
Biochim. Biophys. Acta
1676
1-11
2004
Homo sapiens (Q86W56)
Haince, J.F.; Ouellet, M.E.; McDonald, D.; Hendzel, M.J.; Poirier, G.G.
Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage
Biochim. Biophys. Acta
1763
226-237
2006
Bos taurus, Homo sapiens
Bonicalzi, M.E.; Vodenicharov, M.; Coulombe, M.; Gagne, J.P.; Poirier, G.G.
Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases
Biol. Cell.
95
635-644
2003
Bos taurus
Sevigny, M.B.; Silva, J.M.; Lan, W.C.; Alano, C.C.; Swanson, R.A.
Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells
Brain Res. Mol. Brain Res.
117
213-220
2003
Mus musculus
Meyer-Ficca, M.L.; Meyer, R.G.; Coyle, D.L.; Jacobson, E.L.; Jacobson, M.K.
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments
Exp. Cell Res.
297
521-532
2004
Homo sapiens (Q86W56), Homo sapiens
Oka, S.; Kato, J.; Moss, J.
Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase
J. Biol. Chem.
281
705-713
2006
Mus musculus (Q8CG72), Homo sapiens (Q9NX46), Homo sapiens
Koh, D.W.; Coyle, D.L.; Mehta, N.; Ramsinghani, S.; Kim, H.; Slama, J.T.; Jacobson, M.K.
SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase
J. Med. Chem.
46
4322-4332
2003
Bos taurus
Di Meglio, S.; Denegri, M.; Vallefuoco, S.; Tramontano, F.; Scovassi, A.I.; Quesada, P.
Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells
Mol. Cell. Biochem.
248
85-91
2003
Rattus norvegicus
Cortes, U.; Tong, W.M.; Coyle, D.L.; Meyer-Ficca, M.L.; Meyer, R.G.; Petrilli, V.; Herceg, Z.; Jacobson, E.L.; Jacobson, M.K.; Wang, Z.Q.
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice
Mol. Cell. Biol.
24
7163-7178
2004
Mus musculus
Ying, W.; Sevigny, M.B.; Chen, Y.; Swanson, R.A.
Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death
Proc. Natl. Acad. Sci. USA
98
12227-12232
2001
Mus musculus
Shirato, M.; Tozawa, S.; Maeda, D.; Watanabe, M.; Nakagama, H.; Masutani, M.
Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity
Biochem. Biophys. Res. Commun.
355
451-456
2007
Rattus norvegicus
St-Laurent, J.F.; Gagnon, S.N.; Dequen, F.; Hardy, I.; Desnoyers, S.
Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression
DNA Repair
6
329-343
2007
Caenorhabditis elegans (Q867X0), Caenorhabditis elegans (Q9N5L4), Caenorhabditis elegans
Meyer, R.G.; Meyer-Ficca, M.L.; Whatcott, C.J.; Jacobson, E.L.; Jacobson, M.K.
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity
Exp. Cell Res.
313
2920-2936
2007
Homo sapiens
Gao, H.; Coyle, D.L.; Meyer-Ficca, M.L.; Meyer, R.G.; Jacobson, E.L.; Wang, Z.Q.; Jacobson, M.K.
Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase
Exp. Cell Res.
313
984-996
2007
Mus musculus
Cuzzocrea, S.; Mazzon, E.; Genovese, T.; Crisafulli, C.; Min, W.K.; Di Paola, R.; Muia, C.; Li, J.H.; Malleo, G.; Xu, W.; Massuda, E.; Esposito, E.; Zhang, J.; Wang, Z.Q.
Role of poly(ADP-ribose) glycohydrolase in the development of inflammatory bowel disease in mice
Free Radic. Biol. Med.
42
90-105
2007
Mus musculus
Tulin, A.; Naumova, N.M.; Menon, A.K.; Spradling, A.C.
Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing
Genetics
172
363-371
2006
Drosophila melanogaster
Keil, C.; Groebe, T.; Oei, S.L.
MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1
J. Biol. Chem.
281
34394-34405
2006
Homo sapiens (Q0MQR4)
Cuzzocrea, S.; Genovese, T.; Mazzon, E.; Crisafulli, C.; Min, W.; Di Paola, R.; Muia, C.; Li, J.H.; Esposito, E.; Bramanti, P.; Xu, W.; Massuda, E.; Zhang, J.; Wang, Z.Q.
Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma
J. Pharmacol. Exp. Ther.
319
127-138
2006
Mus musculus
Fisher, A.E.; Hochegger, H.; Takeda, S.; Caldecott, K.W.
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
Mol. Cell. Biol.
27
5597-5605
2007
Homo sapiens
Ono, T.; Kasamatsu, A.; Oka, S.; Moss, J.
The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
Homo sapiens
Formentini, L.; Arapistas, P.; Pittelli, M.; Jacomelli, M.; Pitozzi, V.; Menichetti, S.; Romani, A.; Giovannelli, L.; Moroni, F.; Chiarugi, A.
Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death
Br. J. Pharmacol.
155
1235-1249
2008
Bos taurus
Cohausz, O.; Blenn, C.; Malanga, M.; Althaus, F.R.
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death
Cell. Mol. Life Sci.
65
644-655
2008
Homo sapiens
Burns, D.M.; Ying, W.; Kauppinen, T.M.; Zhu, K.; Swanson, R.A.
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase
PLoS ONE
4
e4896
2009
Mus musculus
Adams-Phillips, L.; Briggs, A.G.; Bent, A.F.
Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis to biotic stress
Plant Physiol.
152
267-280
2010
Arabidopsis thaliana
Okita, N.; Ashizawa, D.; Ohta, R.; Abe, H.; Tanuma, S.
Discovery of novel poly(ADP-ribose) glycohydrolase inhibitors by a quantitative assay system using dot-blot with anti-poly(ADP-ribose)
Biochem. Biophys. Res. Commun.
392
485-489
2010
Bos taurus
Whatcott, C.J.; Meyer-Ficca, M.L.; Meyer, R.G.; Jacobson, M.K.
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence
Exp. Cell Res.
315
3477-3485
2009
Homo sapiens
Erdelyi, K.; Bai, P.; Kovacs, I.; Szabo, E.; Mocsar, G.; Kakuk, A.; Szabo, C.; Gergely, P.; Virag, L.
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells
FASEB J.
23
3553-3563
2009
Homo sapiens
Frizzell, K.M.; Gamble, M.J.; Berrocal, J.G.; Zhang, T.; Krishnakumar, R.; Cen, Y.; Sauve, A.A.; Kraus, W.L.
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells
J. Biol. Chem.
284
33926-33938
2009
Homo sapiens
Botta, D.; Jacobson, M.K.
Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase
Biochemistry
49
7674-7682
2010
Homo sapiens
Blenn, C.; Wyrsch, P.; Bader, J.; Bollhalder, M.; Althaus, F.R.
Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death
Cell. Mol. Life Sci.
68
1455-1466
2011
Mus musculus
Steffen, J.D.; Coyle, D.L.; Damodaran, K.; Beroza, P.; Jacobson, M.K.
Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG)
J. Med. Chem.
54
5403-5413
2011
Homo sapiens
Slade, D.; Dunstan, M.; Barkauskaite, E.; Weston, R.; Lafite, P.; Dixon, N.; Ahel, M.; Leys, D.; Ahel, I.
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
Nature
477
616-622
2011
Homo sapiens, Thermomonospora curvata
Li, G.; Nasar, V.; Yang, Y.; Li, W.; Liu, B.; Sun, L.; Li, D.; Song, F.
Arabidopsis poly(ADP-ribose) glycohydrolase 1 is required for drought, osmotic and oxidative stress responses
Plant Sci.
180
283-291
2011
Arabidopsis thaliana
Okita, N.; Ohta, R.; Ashizawa, D.; Yamada, Y.; Abe, H.; Abe, T.; Tanuma, S.
Bacterial production of recombinant human poly(ADP-ribose) glycohydrolase
Protein Expr. Purif.
75
230-235
2011
Homo sapiens (Q86W56), Homo sapiens
Hassler, M.; Jankevicius, G.; Ladurner, A.G.
PARG: A macrodomain in disguise
Structure
19
1351-1353
2011
Thermomonospora curvata
Finch, K.E.; Knezevic, C.E.; Nottbohm, A.C.; Partlow, K.C.; Hergenrother, P.J.
Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG)
ACS Chem. Biol.
7
563-570
2012
Homo sapiens
Huang, H.; Hu, G.; Cai, J.; Xia, B.; Liu, J.; Li, X.; Gao, W.; Zhang, J.; Liu, Y.; Zhuang, Z.
Role of poly(ADP-ribose) glycohydrolase silencing in DNA hypomethylation induced by benzo(a)pyrene
Biochem. Biophys. Res. Commun.
452
708-714
2014
Homo sapiens
Islam, R.; Koizumi, F.; Kodera, Y.; Inoue, K.; Okawara, T.; Masutani, M.
Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors
Bioorg. Med. Chem. Lett.
24
3802-3806
2014
Rattus norvegicus
Sahaboglu, A.; Tanimoto, N.; Bolz, S.; Garrido, M.G.; Ueffing, M.; Seeliger, M.W.; Loewenheim, H.; Ekstroem, P.; Paquet-Durand, F.
Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors
Cell Death Dis.
5
e1234
2014
Mus musculus
Huang, H.Y.; Cai, J.F.; Liu, Q.C.; Hu, G.H.; Xia, B.; Mao, J.Y.; Wu, D.S.; Liu, J.J.; Zhuang, Z.X.
Role of poly(ADP-ribose) glycohydrolase in the regulation of cell fate in response to benzo(a)pyrene
Exp. Cell Res.
318
682-690
2012
Homo sapiens (Q86W56), Homo sapiens
Ji, Y.; Jarnik, M.; Tulin, A.V.
Poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-interacting protein Hrp38 regulate pattern formation during Drosophila eye development
Gene
526
187-194
2013
Drosophila melanogaster
Feng, X.; Koh, D.W.
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells
Int. J. Oncol.
42
749-756
2013
Homo sapiens
Hou, Q.; Hu, X.; Sheng, X.; Liu, Y.; Liu, C.
Theoretical study on the degradation of ADP-ribose polymer catalyzed by poly(ADP-ribose) glycohydrolase
J. Mol. Graph. Model.
42
26-31
2013
Thermomonospora curvata (D1AC29)
Kim, I.K.; Kiefer, J.R.; Ho, C.M.; Stegeman, R.A.; Classen, S.; Tainer, J.A.; Ellenberger, T.
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element
Nat. Struct. Mol. Biol.
19
653-656
2012
Rattus norvegicus (Q9QYM2)
Dunstan, M.S.; Barkauskaite, E.; Lafite, P.; Knezevic, C.E.; Brassington, A.; Ahel, M.; Hergenrother, P.J.; Leys, D.; Ahel, I.
Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase
Nat. Commun.
3
878
2012
Tetrahymena thermophila (I6L8L8), Tetrahymena thermophila
Tucker, J.A.; Bennett, N.; Brassington, C.; Durant, S.T.; Hassall, G.; Holdgate, G.; McAlister, M.; Nissink, J.W.; Truman, C.; Watson, M.
Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives
PLoS ONE
7
e50889
2012
Homo sapiens (Q86W56), Homo sapiens
Vilchez Larrea, S.C.; Schlesinger, M.; Kevorkian, M.L.; Flawia, M.M.; Alonso, G.D.; Fernandez Villamil, S.H.
Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle
PLoS ONE
8
e67356
2013
Trypanosoma cruzi (Q0PW90), Trypanosoma cruzi
Dahl, M.; Maturi, V.; Loenn, P.; Papoutsoglou, P.; Zieba, A.; Vanlandewijck, M.; van der Heide, L.P.; Watanabe, Y.; Soederberg, O.; Hottiger, M.O.; Heldin, C.H.; Moustakas, A.
Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor beta signaling
PLoS ONE
9
e103651
2014
Homo sapiens
Wang, Z.; Gagne, J.P.; Poirier, G.G.; Xu, W.
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase
PLoS ONE
9
e86010
2014
Mus musculus (O88622), Mus musculus
James, D.I.; Smith, K.M.; Jordan, A.M.; Fairweather, E.E.; Griffiths, L.A.; Hamilton, N.S.; Hitchin, J.R.; Hutton, C.P.; Jones, S.; Kelly, P.; McGonagle, A.E.; Small, H.; Stowell, A.I.; Tucker, J.; Waddell, I.D.; Waszkowycz, B.; Ogilvie, D.J.
First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib
ACS Chem. Biol.
11
3179-3190
2016
Homo sapiens (Q86W56)
Stowell, A.I.; James, D.I.; Waddell, I.D.; Bennett, N.; Truman, C.; Hardern, I.M.; Ogilvie, D.J.
A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase
Anal. Biochem.
503
58-64
2016
Homo sapiens (Q86W56), Homo sapiens
Araiza-Cervantes, C.; Meza-Carmen, V.; Martinez-Cadena, G.; Roncero, M.; Reyna-Lopez, G.; Franco, B.
Biochemical and genetic analysis of a unique poly(ADP-ribosyl) glycohydrolase (PARG) of the pathogenic fungus Fusarium oxysporum f. sp. lycopersici
Antonie Van Leeuwenhoek
111
285-295
2018
Fusarium oxysporum f. sp. lycopersici (A0A0D2XPQ9), Fusarium oxysporum f. sp. lycopersici 4287 (A0A0D2XPQ9), Fusarium oxysporum f. sp. lycopersici FGSC 9935 (A0A0D2XPQ9), Fusarium oxysporum f. sp. lycopersici CBS 123668 (A0A0D2XPQ9), Fusarium oxysporum f. sp. lycopersici NRRL 34936 (A0A0D2XPQ9)
-
Gravells, P.; Grant, E.; Smith, K.M.; James, D.I.; Bryant, H.E.
Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase
DNA Repair
52
81-91
2017
Homo sapiens (Q86W56)
Lambrecht, M.J.; Brichacek, M.; Barkauskaite, E.; Ariza, A.; Ahel, I.; Hergenrother, P.J.
Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase
J. Am. Chem. Soc.
137
3558-3564
2015
Homo sapiens (Q86W56), Homo sapiens
Kim, I.; Stegeman, R.; Brosey, C.; Ellenberger, T.
A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase
J. Biol. Chem.
290
3775-3783
2015
Rattus norvegicus (Q9QYM2)
-
Pourfarjam, Y.; Ventura, J.; Kurinov, I.; Cho, A.; Moss, J.; Kim, I.K.
Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition
J. Biol. Chem.
293
12350-12359
2018
Homo sapiens (Q9NX46), Homo sapiens
Wang, M.; Yuan, Z.; Xie, R.; Ma, Y.; Liu, X.; Yu, X.
Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation
J. Biol. Chem.
293
14470-14480
2018
Homo sapiens (Q9NX46)
Waszkowycz, B.; Smith, K.M.; McGonagle, A.E.; Jordan, A.M.; Acton, B.; Fairweather, E.E.; Griffiths, L.A.; Hamilton, N.M.; Hamilton, N.S.; Hitchin, J.R.; Hutton, C.P.; James, D.I.; Jones, C.D.; Jones, S.; Mould, D.P.; Small, H.F.; Stowell, A.I.J.; Tucker, J.A.; Waddell, I.D.; Ogilvie, D.J.
Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG) discovery and optimization of orally bioavailable quinazolinedione sulfonamides
J. Med. Chem.
61
10767-10792
2018
Homo sapiens (Q86W56), Homo sapiens
Barkauskaite, E.; Jankevicius, G.; Ahel, I.
Structures and mechanisms of enzymes employed in the synthesis and degradation of PARP-dependent protein ADP-ribosylation
Mol. Cell
58
935-946
2015
Homo sapiens (Q86W56)
Chaudhuri, A.; Ahuja, A.; Herrador, R.; Lopes, M.
Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase
Mol. Cell. Biol.
35
856-865
2015
Homo sapiens (Q86W56)
-
Cho, C.C.; Chien, C.Y.; Chiu, Y.C.; Lin, M.H.; Hsu, C.H.
Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
Nat. Commun.
10
1491
2019
Deinococcus radiodurans (Q9RZM4), Deinococcus radiodurans, Deinococcus radiodurans R1 (Q9RZM4), Deinococcus radiodurans DSM 20539 (Q9RZM4), Deinococcus radiodurans VKM B-1422 (Q9RZM4), Deinococcus radiodurans NCIMB 9279 (Q9RZM4), Deinococcus radiodurans JCM 16871 (Q9RZM4), Deinococcus radiodurans LMG 4051 (Q9RZM4), Deinococcus radiodurans ATCC 13939 (Q9RZM4), Deinococcus radiodurans NBRC 15346 (Q9RZM4)
Rotin, L.E.; Gronda, M.; MacLean, N.; Hurren, R.; Wang, X.; Lin, F.H.; Wrana, J.; Datti, A.; Barber, D.L.; Minden, M.D.; Slassi, M.; Schimmer, A.D.
Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism
Oncotarget
7
2765-2779
2016
Homo sapiens (Q86W56)
Li, X.; Li, X.; Zhu, Z.; Huang, P.; Zhuang, Z.; Liu, J.; Gao, W.; Liu, Y.; Huang, H.
Poly(ADP-Ribose) glycohydrolase (PARG) silencing suppresses benzo(a)pyrene induced cell transformation
PLoS ONE
11
e0151172
2016
Homo sapiens (Q86W56), Homo sapiens
Zhang, H.; Gu, Z.; Wu, Q.; Yang, L.; Liu, C.; Ma, H.; Xia, Y.; Ge, X.
Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation
Sci. Rep.
5
15892
2015
Arabidopsis thaliana (Q9SKB3), Arabidopsis thaliana Col-0 (Q9SKB3)
html completed
