3.2.1.143: poly(ADP-ribose) glycohydrolase

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For detailed information about poly(ADP-ribose) glycohydrolase, go to the full flat file.

Reaction

Synonyms

ADP-ribose glycohydrolase, ADP-ribosyl-acceptor hydrolase 3, ADPRHL2, ARH3, DrPARG, FOXG_05947, Genbank AB019366-derived protein GI 6518480, Genbank U78975-derived protein GI 2062407, glycohydrolase, poly(adenosine diphosphoribose), glycohydrolase, poly(adenosine diphosphoribose) (cattle clone 4/5), glycohydrolase, poly(adenosine diphosphoribose) (Rattus norvegicus strain BUF gene Parg), PAR glycohydrolase, PAR glyco�hydrolase, PARG, PARG1, PARG110, PARG111, PARG59, poly (ADP-ribose) glycohydrolase, poly(adenosine diphosphoribose) glycohydrolase, poly(adenosine diphosphoribose) glycosidase, poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31860), poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31870), poly(ADP-ribose) glycohydrolase (cattly clone 4/5), poly(ADP-ribose) glycohydrolase 1, poly(ADP-ribose)glycohydrolase, poly(ADP-ribosyl) glycohydrolase, poly-ADP-glycohydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.143 poly(ADP-ribose) glycohydrolase

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Results	in table
20	Activating Compound
4069	AA Sequence
16	Application
5	CAS Registry Number
21	Cloned(Commentary)
10	Crystallization (Commentary)
178	Disease/ Diagnostics
11	Expression
91	General Information
1	General Stability
58	IC50 Value
317	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
20	KM Value [mM]
49	Localization
13	Metals/Ions
23	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
101	Organism
85	PDB ID
17	pH Optimum
4	pH Range
2	pH Stability
1	Posttranslational Modification
124	Protein Variants
19	Purification (Commentary)
16	Reaction
4	Reaction Type
99	Reference
84	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
113	Substrates and Products (Substrate)
22	Subunits
123	Synonyms
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
4	Turnover Number [1/s]

Expression

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Expression on EC 3.2.1.143 - poly(ADP-ribose) glycohydrolase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

9 entries

PARG1 expression is induced primarily in root and shoot meristems by bleomycin and induction of PARG1 is dependent on ATM and ATR kinases. PARG1 is induced primarily in mitotically active cells

2 entries

in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans

Q9RZM4

754824

in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans R1

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans DSM 20539

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans VKM B-1422

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans NCIMB 9279

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans JCM 16871

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans LMG 4051

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans ATCC 13939

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in the radio-resistant bacterium Deinococcus radiodurans, the PARG homologue, DrPARG, expression is upregulated after radiation damage

Deinococcus radiodurans NBRC 15346

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PARG1 expression is induced primarily in root and shoot meristems by bleomycin and induction of PARG1 is dependent on ATM and ATR kinases. PARG1 is induced primarily in mitotically active cells

Arabidopsis thaliana

Q9SKB3

755409

PARG1 expression is induced primarily in root and shoot meristems by bleomycin and induction of PARG1 is dependent on ATM and ATR kinases. PARG1 is induced primarily in mitotically active cells

Arabidopsis thaliana Col-0

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