3.2.1.143: poly(ADP-ribose) glycohydrolase

This is an abbreviated version!
For detailed information about poly(ADP-ribose) glycohydrolase, go to the full flat file.

Reaction

Synonyms

ADP-ribose glycohydrolase, ADP-ribosyl-acceptor hydrolase 3, ADPRHL2, ARH3, DrPARG, FOXG_05947, Genbank AB019366-derived protein GI 6518480, Genbank U78975-derived protein GI 2062407, glycohydrolase, poly(adenosine diphosphoribose), glycohydrolase, poly(adenosine diphosphoribose) (cattle clone 4/5), glycohydrolase, poly(adenosine diphosphoribose) (Rattus norvegicus strain BUF gene Parg), PAR glycohydrolase, PAR glyco�hydrolase, PARG, PARG1, PARG110, PARG111, PARG59, poly (ADP-ribose) glycohydrolase, poly(adenosine diphosphoribose) glycohydrolase, poly(adenosine diphosphoribose) glycosidase, poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31860), poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31870), poly(ADP-ribose) glycohydrolase (cattly clone 4/5), poly(ADP-ribose) glycohydrolase 1, poly(ADP-ribose)glycohydrolase, poly(ADP-ribosyl) glycohydrolase, poly-ADP-glycohydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.143 poly(ADP-ribose) glycohydrolase

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Results	in table
20	Activating Compound
4069	AA Sequence
16	Application
5	CAS Registry Number
21	Cloned(Commentary)
10	Crystallization (Commentary)
178	Disease/ Diagnostics
11	Expression
91	General Information
1	General Stability
58	IC50 Value
317	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
20	KM Value [mM]
49	Localization
13	Metals/Ions
23	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
101	Organism
85	PDB ID
17	pH Optimum
4	pH Range
2	pH Stability
1	Posttranslational Modification
124	Protein Variants
19	Purification (Commentary)
16	Reaction
4	Reaction Type
99	Reference
84	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
113	Substrates and Products (Substrate)
22	Subunits
123	Synonyms
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.2.1.143 - poly(ADP-ribose) glycohydrolase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0045

(3Z)-5-bromo-1-(2,6-dichlorobenzyl)-3-[4-oxo-3-[2-(1H-tetrazol-5-yl)ethyl]-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.0123

(3Z)-5-chloro-1-(2,6-dichlorobenzyl)-3-[4-oxo-3-[2-(1H-tetrazol-5-yl)ethyl]-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.000026

1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

Homo sapiens

Q86W56

pH 7.4, 22°C

752360

0.00004

1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1H-benzimidazole-5-sulfonamide

Homo sapiens

Q86W56

pH 7.4, 22°C

752360

0.072

2-(3-chloro-4-(naphthalen-2-yloxy)phenylcarbamoyl)benzoic acid

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.025

3,5-dichloro-2-hydroxy-N-(3-methyl-4-(naphthalen-2-yloxy)phenyl)benzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.021

3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)-3-(trifluoromethyl)phenyl)benzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.042

3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)phenyl)benzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.14

3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxy-N-methylbenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.012

3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.026

3,5-dichloro-N-(3-chloro-4-(p-tolyloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.061

3,5-dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.261

3,5-dichloro-N-(3-chlorophenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.027

3,5-dichloro-N-(3-fluoro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.5

3,5-dichloro-N-(4-chlorophenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.012

3,5-dichloro-N-[3-chloro-4-(naphthalen-2-yloxy)phenyl]-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.022

3-bromo-5-chloro-N-[5-chloro-2-[(1-chloronaphthalen-2-yl)oxy]phenyl]-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.026

3-bromo-N-[2-[2-bromo-6-methyl-3-(propan-2-yl)phenoxy]-5-chlorophenyl]-5-chloro-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.061

3-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.95

3-galloyl-D-glucose

Bos taurus

-

enzyme for 240 min at 37°C

697031

0.0465

3-[(5Z)-5-[1-(2-chlorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.0029

3-[(5Z)-5-[5-bromo-1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.003

3-[(5Z)-5-[5-bromo-1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.0058

3-[(5Z)-5-[5-chloro-1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid

Homo sapiens

-

pH not specified in the publication, 37°C

731037

0.117

5-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.0163

8-n-octyl-amino-adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol

Homo sapiens

Q86W56

with wild-type enzyme, pH 7.0, 25°C

732714

0.0011 - 0.0031

adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol

2 entries

0.00012

adenosine 5'-diphosphate-(hydroxymethyl)-pyrrolidinediol

Mus musculus

O88622

pH and temperature not specified in the publication

732776

0.0001

adenosine diphosphate (hydroxymethyl) pyrrolidinediol

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.00066

adenosine diphosphate (hydroxymethyl)pyrrolidinediol

Bos taurus

-

37°C

707395

0.00012

ADP-(hydroxymethyl)pyrrolidinediol

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

3.2

ADP-HPD

Bos taurus

-

enzyme for 240 min at 37°C

697031

0.0019

eosine Y

Bos taurus

-

37°C

707395

7.2

methyl 2-O-galloyl-beta-D-glucoside

Bos taurus

-

enzyme for 240 min at 37°C

697031

7.1

methyl 3-O-galloyl-beta-D-glucoside

Bos taurus

-

enzyme for 240 min at 37°C

697031

0.0031

N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0028

N'',N'''-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]carbonohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0016

N'1,N'3-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0154

N'1,N'3-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]propanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0098

N'1,N'4-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]butanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0082

N'1,N'4-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]butanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0139

N'1,N'5-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]pentanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0274

N'1,N'5-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]pentanedihydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0031

N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.001

N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0148

N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0188

N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0099

N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0401

N'1-[(E)-(2,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0032

N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0021

N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'4-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.0192

N'1-[(E)-(3,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide

Rattus norvegicus

-

pH 7.5, 37°C

731453

0.5

N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.06

N-tert-butyl-9,10-dioxo-9,10-dihydroanthracene-2-sulfonamide

Homo sapiens

Q86W56

pH 7.4, 22°C

752360

0.08

N-[4-[(3-bromonaphthalen-2-yl)oxy]-3-chlorophenyl]-3,5-dichloro-2-hydroxybenzamide

Homo sapiens

-

in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C

715869

0.0000026

PDD00017273

Homo sapiens

Q86W56

pH and temperature not specified in the publication

753397

0.005

phloxine B

Bos taurus

-

37°C

707395

0.0011

adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol

Homo sapiens

Q86W56

with mutant enzyme K616A/Q617A/K618A/E688A/K689A/K690A, pH 7.0, 25°C

732714

0.0031

adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol

Homo sapiens

Q86W56

with wild-type enzyme, pH 7.0, 25°C

732714