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3.2.1.143: poly(ADP-ribose) glycohydrolase

This is an abbreviated version!
For detailed information about poly(ADP-ribose) glycohydrolase, go to the full flat file.

Word Map on EC 3.2.1.143

Reaction

(ADP-ribose)n
+
H2O
=
(ADP-ribose)n-1
+
ADP-ribose

Synonyms

ADP-ribose glycohydrolase, ADP-ribosyl-acceptor hydrolase 3, ADPRHL2, ARH3, DrPARG, FOXG_05947, Genbank AB019366-derived protein GI 6518480, Genbank U78975-derived protein GI 2062407, glycohydrolase, poly(adenosine diphosphoribose), glycohydrolase, poly(adenosine diphosphoribose) (cattle clone 4/5), glycohydrolase, poly(adenosine diphosphoribose) (Rattus norvegicus strain BUF gene Parg), PAR glycohydrolase, PAR glyco­hydrolase, PARG, PARG1, PARG110, PARG111, PARG59, poly (ADP-ribose) glycohydrolase, poly(adenosine diphosphoribose) glycohydrolase, poly(adenosine diphosphoribose) glycosidase, poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31860), poly(ADP-ribose) glycohydrolase (Arabidopsis thaliana gene At2g31870), poly(ADP-ribose) glycohydrolase (cattly clone 4/5), poly(ADP-ribose) glycohydrolase 1, poly(ADP-ribose)glycohydrolase, poly(ADP-ribosyl) glycohydrolase, poly-ADP-glycohydrolase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.143 poly(ADP-ribose) glycohydrolase

Substrates Products

Substrates Products on EC 3.2.1.143 - poly(ADP-ribose) glycohydrolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(ADP-D-ribose)15 + H2O
(ADP-ribose)14 + ADP-D-ribose
show the reaction diagram
2'-O-(ADP-ribosyl)-adenosine 5'-phosphate + H2O
?
show the reaction diagram
-
-
-
?
2'-O-acetyl-ADP-ribose + H2O
ADP-ribose + acetate
show the reaction diagram
-
rate of hydrolysis by isoform ARH3 is 250fold that observed with isoform ARH1, isoform ARH2 is inactive with this substrate
-
-
?
ADP-ribose dimer + H2O
2 ADP-ribose
show the reaction diagram
the N-1 adenine group interacts with the amide nitrogen of the conserved Leu752 in human PARG, while the beta-phosphate forms H-bonds with the conserved Ala750, enzyme-substrate binding structure, crystal structure analysis, overview
-
-
?
histone-bound poly(ADP-ribose) + H2O
ADP-ribose + ADP-ribose oligomer + ?
show the reaction diagram
-
C14-labelled poly(ADP-ribose) produced by PARP-1 (poly(ADP-ribose) polymerase) of labelled NAD+
-
-
?
PARP1-XRCC1 + H2O
?
show the reaction diagram
poly(ADP-D-ribose)n + H2O
poly(ADP-D-ribose)n-1 + ADP-ribose
show the reaction diagram
poly(ADP-ribose) + H2O
?
show the reaction diagram
poly(ADP-ribose) + H2O
ADP-ribose + ADP-ribose oligomer
show the reaction diagram
poly(ADP-ribose) + H2O
ADP-ribose oligomer + ADP-ribose
show the reaction diagram
poly(ADP-ribose)n + H2O
?
show the reaction diagram
poly(ADP-ribose)n + H2O
ADP-ribose
show the reaction diagram
poly(ADP-ribose)n-poly(ADP-ribose) polymerase + H2O
ADP-ribose + poly(ADP-ribose) polymerase
show the reaction diagram
-
-
-
?
poly(ADP-ribosyl)ated-Hrp38 + H2O
?
show the reaction diagram
-
-
-
-
?
propargyl ADP-ribose dimer + H2O
propargyl ADP-ribose + ADP-ribose
show the reaction diagram
-
-
-
?
additional information
?
-