3.1.6.14: N-acetylglucosamine-6-sulfatase
This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.14
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3.1.6.14
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proteoglycans
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sulfatases
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6-o-sulfation
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sulf-2
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mucopolysaccharidosis
-
arylsulfatase
-
sanfilippo
-
medicine
-
hspgs
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trisulfated
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naglu
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hgsnat
-
sulfamidase
- 3.1.6.14
- proteoglycans
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sulfatases
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6-o-sulfation
-
sulf-2
- mucopolysaccharidosis
- arylsulfatase
-
sanfilippo
- medicine
-
hspgs
-
trisulfated
- naglu
- hgsnat
-
sulfamidase
Reaction
Synonyms
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparan sulfate 6-O-endosulfatase, heparan sulfate 6-O-endosulfatase1, heparin/heparan sulfate 6-O-sulfatase, HS 6-O-endosulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, Sulf-1, sulfatase, acetylglucosamine 6-
ECTree
3.1.6.14 N-acetylglucosamine-6-sulfataseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl N-acetyl-beta-D-glucosamine 6-sulfate + H2O
4-methylumbelliferyl N-acetyl-beta-D-glucosamine + sulfate
-
-
-
-
?
beta-D-GlcNAc6S-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + H2O
beta-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + sulfate
-
-
-
-
?
N-acetyl galactosamine 6-sulfate + H2O
N-acetyl galactosamine + sulfate
-
very low activity in cultured skin fibroblasts
-
-
?
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idonic acid + H2O
O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
-
-
-
?
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose + H2O
O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate + H2O
O-(alpha-N-acetyl glucosamine)-(1-4)-L-idose-2-sulfate + sulfate
-
same activity in cultured skin fibroblasts compared to monosaccharides
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + H2O
O-(alpha-N-acetyl glucosamine)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + sulfate
-
30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides
-
-
?
O-(beta-N-acetyl glucosamine 6-sulfate)-(1-3)-D-galactitol + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-D-galactitol + sulfate
-
activity 100-fold less
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
trisaccharide with an N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with an N-acetylglucosamine + sulfate
-
-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
-
fluorogenic substrate
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
fluorogenic substrate 4-MUS
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
-
no activity detected in cultured skin fibroblasts
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
-
about 55% of the activity with N-acetyl-D-glucosamine 6-sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
lower activity in cultured skin fibroblasts compared to trisaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
higher activity in liver compared to trisaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
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in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
acts also as endosulfatase
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
catalyzes hydrolysis of sulfate from internal N-acetylglucosamine 6-sulfate at a lower rate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
in substrates bearing a N-acetylglucosamine 6-sulfate residue at its nonreducing terminus derived from heparan sulfate and keratan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
specific exosulfatase for desulfation of the nonreducing terminal N-acetylglucosamine 6-sulfate residues of heparansulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
different enzymatic activities towards oligosaccharides derived from keratan sulfate or heparan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
has no activity towards heparin, heparansulfate and keratansulfate, increase of activity in monosulfated tetra- or trisaccharides, maximum activity in sulfated monosaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
non-arylsulfatase
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
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in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
different enzymatic hydrolysis for heparan sulfate and keratan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
Tagelus gibbus
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
Tagelus gibbus
-
acts on polymer chain prior to depolymerization
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
-
N-sulfated and N-acetylated derivates of
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
-
30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
-
lower activity in liver compared to monosaccharides
-
-
?
additional information
?
-
-
involved in catabolism of heparan sulfate
-
?
additional information
?
-
-
the enzyme shows O-desulphation activity towards heparan sulphate-derived saccharides. No activity with glucose 3-sulfate, galactose 4-sulfate, galactose 6-sulfate and N-acetylgalactosamine 4-sulfate
-
-
?
additional information
?
-
involved in degradation of heparan sulfate, causing Mucopolysaccharidosis type IIID
-
-
?
additional information
?
-
-
involved in degradation of heparan sulfate, causing Mucopolysaccharidosis type IIID
-
-
?
additional information
?
-
-
heparin/heparan sulfate 6-O-sulfatase is a predominantly exolytic enzyme that specifically acts on N-sulfated or N-acetylated 6-O-sulfated glucosamines present at the non-reducing end of heparin and heparan sulfate glycosaminoglycan oligosaccharide substrates
-
-
?
