3.1.6.14: N-acetylglucosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.

Reaction

Synonyms

2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparan sulfate 6-O-endosulfatase, heparan sulfate 6-O-endosulfatase1, heparin/heparan sulfate 6-O-sulfatase, HS 6-O-endosulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, Sulf-1, sulfatase, acetylglucosamine 6-

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.14 N-acetylglucosamine-6-sulfatase

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Results	in table
3	Activating Compound
1102	AA Sequence
8	Application
1	CAS Registry Number
4	Cloned(Commentary)
121	Disease/ Diagnostics
1	Expression
1	General Information
3	General Stability
2	IC50 Value
24	Inhibitors
20	KM Value [mM]
9	Localization
2	Metals/Ions
24	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
27	Organism
2	Pathway
1	PDB ID
18	pH Optimum
1	pH Range
5	pH Stability
1	pI Value
6	Posttranslational Modification
6	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
26	Reference
43	Source Tissue
10	Specific Activity [micromol/min/mg]
3	Storage Stability
73	Substrates and Products (Substrate)
7	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

5 entries

additional information

?

-

Homo sapiens

-

involved in catabolism of heparan sulfate

652758

-

652758

?

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

Bos taurus

-

-

135580, 135591

-

-

?

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

Capra hircus

-

-

135588, 135594

-

-

?

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

Homo sapiens

-

in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate

135579, 135580, 135581, 135582, 135583, 135584, 135585, 135586, 135587, 135589, 135590

-

-

?

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

Homo sapiens

-

different enzymatic hydrolysis for heparan sulfate and keratan sulfate

135584

-

-

?

N-acetyl-D-glucosamine 6-sulfate units + H2O

N-acetyl-D-glucosamine units + sulfate

Tagelus gibbus

-

-

135592

-

-

?