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Literature summary for 3.1.6.14 extracted from

  • Kresse, H.; Paschke, E.; von Figura, K.; Gilberg, W.; Fuchs, W.
    Sanfilippo disease type D: deficiency of N-acetylglucosamine-6-sulfate sulfatase required for heparan sulfate degradation (1980), Proc. Natl. Acad. Sci. USA, 77, 6822-6826.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-sulfate units + H2O Homo sapiens in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate N-acetyl-D-glucosamine units + sulfate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast in culture Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-GlcNAc6S-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + H2O
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 Homo sapiens beta-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + sulfate
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 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O different enzymatic activities towards oligosaccharides derived from keratan sulfate or heparan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
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 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
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 ?