3.1.6.14: N-acetylglucosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.14

3.1.6.14

proteoglycans

sulfatases

6-o-sulfation

sulf-2

mucopolysaccharidosis

arylsulfatase

sanfilippo

medicine

hspgs

trisulfated

naglu

hgsnat

sulfamidase

Reaction

Synonyms

2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparan sulfate 6-O-endosulfatase, heparan sulfate 6-O-endosulfatase1, heparin/heparan sulfate 6-O-sulfatase, HS 6-O-endosulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, Sulf-1, sulfatase, acetylglucosamine 6-

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.14 N-acetylglucosamine-6-sulfatase

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Results	in table
3	Activating Compound
1102	AA Sequence
8	Application
1	CAS Registry Number
4	Cloned(Commentary)
121	Disease/ Diagnostics
1	Expression
1	General Information
3	General Stability
2	IC50 Value
24	Inhibitors
20	KM Value [mM]
9	Localization
2	Metals/Ions
24	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
27	Organism
2	Pathway
1	PDB ID
18	pH Optimum
1	pH Range
5	pH Stability
1	pI Value
6	Posttranslational Modification
6	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
26	Reference
43	Source Tissue
10	Specific Activity [micromol/min/mg]
3	Storage Stability
73	Substrates and Products (Substrate)
7	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]

Localization

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Localization on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

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cell membrane

Homo sapiens

P15586

the heterodimeric enzyme is released in extracellular environment and/or retained at the cell membrane, probably by interaction with cell surface heparan sulfate

the heterodimeric enzyme is released in extracellular environment and/or retained at the cell membrane, probably by interaction with cell surface heparan sulfate

26% in fractions of secondary granules, 63% in fractions of primary granules

663957

secondary granule

Homo sapiens

26% in fractions of secondary granules, 63% in fractions of primary granules

663957