3.1.6.14: N-acetylglucosamine-6-sulfatase

This is an abbreviated version, for detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.

Reaction

hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate =

Synonyms

2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparin/heparan sulfate 6-O-sulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, sulfatase, acetylglucosamine 6-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.14 N-acetylglucosamine-6-sulfatase

pH Optimum

pH Optimum on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.9
-
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate in fibroblasts
4.1
-
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate in leucocytes
4.2 - 6
-
depending on substrate structure, overview
4.2
-
in fibroblasts
4.3
-
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate
4.5
-
in leukocytes
4.8
-
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose
5
-
forms: A, B, C
5.1
-
in urine
5.5
-
trisaccharide
5.7
-
glucose 6-sulfate, N-acetylglucosamine 6-sulfate