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Literature summary for 3.1.6.14 extracted from

  • Elliott, H.; Hopwood, J.J.
    Detection of the Sanfilippo D syndrome by the use of a radiolabeled monosaccharide sulfate as the substrate for the estimation of N-acetylglucosamine-6-sulfate sulfatase (1984), Anal. Biochem., 138, 205-209.
    View publication on PubMed

Application

Application Comment Organism
medicine Sanfilippo D Syndrome: N-acetylglucosamine 6-sulfate sulfatase deficiency, mucopolysaccharidosis type IIID Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PO43-
-
Homo sapiens
SO42-
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.33
-
N-acetylglucosamine 6-sulfate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-sulfate units + H2O Homo sapiens in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate N-acetyl-D-glucosamine units + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-
skin fibroblast in culture Homo sapiens
-
urine
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000006
-
N-acetyl galactosamine 6-sulfate of cultured skin fibroblasts Homo sapiens
0.00000052
-
N-acetyl-D-glucosamine 6-sulfate of cultured skin fibroblasts Homo sapiens
0.000001
-
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate of cultured skin fibroblasts Homo sapiens
0.00003
-
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-6-sulfate of cultured skin fibroblasts Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucose 6-sulfate + H2O no activity detected in cultured skin fibroblasts Homo sapiens glucose + sulfate
-
?
N-acetyl galactosamine 6-sulfate + H2O very low activity in cultured skin fibroblasts Homo sapiens N-acetyl galactosamine + sulfate
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O lower activity in cultured skin fibroblasts compared to trisaccharides Homo sapiens N-acetyl-D-glucosamine + sulfate
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
-
Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate + H2O same activity in cultured skin fibroblasts compared to monosaccharides Homo sapiens O-(alpha-N-acetyl glucosamine)-(1-4)-L-idose-2-sulfate + sulfate
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + H2O 30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides Homo sapiens O-(alpha-N-acetyl glucosamine)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + sulfate
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O 30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides Homo sapiens trisaccharide with a N-acetylglucosamine + sulfate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
N-acetylglucosamine 6-sulfate Homo sapiens