Application | Comment | Organism |
---|---|---|
medicine | Sanfilippo D Syndrome: N-acetylglucosamine 6-sulfate sulfatase deficiency, mucopolysaccharidosis type IIID | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PO43- | - |
Homo sapiens | |
SO42- | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
N-acetylglucosamine 6-sulfate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-glucosamine 6-sulfate units + H2O | Homo sapiens | in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate | N-acetyl-D-glucosamine units + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Homo sapiens | - |
skin fibroblast | in culture | Homo sapiens | - |
urine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000006 | - |
N-acetyl galactosamine 6-sulfate of cultured skin fibroblasts | Homo sapiens |
0.00000052 | - |
N-acetyl-D-glucosamine 6-sulfate of cultured skin fibroblasts | Homo sapiens |
0.000001 | - |
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate of cultured skin fibroblasts | Homo sapiens |
0.00003 | - |
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-6-sulfate of cultured skin fibroblasts | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucose 6-sulfate + H2O | no activity detected in cultured skin fibroblasts | Homo sapiens | glucose + sulfate | - |
? | |
N-acetyl galactosamine 6-sulfate + H2O | very low activity in cultured skin fibroblasts | Homo sapiens | N-acetyl galactosamine + sulfate | - |
? | |
N-acetyl-D-glucosamine 6-sulfate + H2O | lower activity in cultured skin fibroblasts compared to trisaccharides | Homo sapiens | N-acetyl-D-glucosamine + sulfate | - |
? | |
N-acetyl-D-glucosamine 6-sulfate units + H2O | - |
Homo sapiens | N-acetyl-D-glucosamine units + sulfate | - |
? | |
N-acetyl-D-glucosamine 6-sulfate units + H2O | in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate | Homo sapiens | N-acetyl-D-glucosamine units + sulfate | - |
? | |
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate + H2O | same activity in cultured skin fibroblasts compared to monosaccharides | Homo sapiens | O-(alpha-N-acetyl glucosamine)-(1-4)-L-idose-2-sulfate + sulfate | - |
? | |
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + H2O | 30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides | Homo sapiens | O-(alpha-N-acetyl glucosamine)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + sulfate | - |
? | |
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O | 30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides | Homo sapiens | trisaccharide with a N-acetylglucosamine + sulfate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
N-acetylglucosamine 6-sulfate | Homo sapiens |