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1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
L-Dopa
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

Molecular Weight

Molecular Weight on EC 1.14.16.2 - tyrosine 3-monooxygenase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
210000 - 211000
225000
-
pheochromocytoma tumors, asymmetric protein, native PAGE, gel filtration and sucrose density gradient centrifugation
239000
-
brain, gel filtration
24000
250000
260000
280000
300000
310000
-
from caudate nucleus, gel filtration
34700
-
catalytic domain, gel filtration
390000
-
from adrenal medulla, form II, gel filtration
54000
-
x * 54000, predicted, 55 kDa from SDS-PAGE of His-tagged version
55000
56000
58000
-
x * 58000, recombinant enzyme, SDS-PAGE
59000
-
4 * 59000, SDS-PAGE
60000
61100
-
2 * 61100 + 2 * 62400, SDS-PAGE
62000
62400
-
2 * 61100 + 2 * 62400, SDS-PAGE
63100
-
4 * 63100, about, recombinant enzyme, sequence calculation and gel filtration
63300
-
4 * 63300, SDS-PAGE
65300
-
calculated from amino acid sequence
66200
-
x * 66200, SDS-PAGE
70000
4 * 70000, SDS-PAGE
98900
-
recombinant enzyme, SDS-PAGE
additional information