1.14.16.2: tyrosine 3-monooxygenase

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For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

1.14.16.2

dopamine

dopaminergic

parkinsonism

nigra

striatum

catecholamine

substantia

nerve

ventral

fiber

sympathetic

innervation

adrenal

noradrenergic

neurotransmitter

6-hydroxydopamine

ganglia

th-positive

catecholaminergic

neuropeptide

norepinephrine

nigrostriatal

midbrain

monoamine

neurotrophic

compacta

coeruleus

hypothalamus

tegmental

mesencephalic

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

l-dopa

6-ohda

neurochemical

accumbens

noradrenaline

rostrally

dopac

apomorphine

perikarya

intrastriatal

beta-hydroxylase

mptp-induced

varicosity

ventrolateral

dopamine-beta-hydroxylase

preoptic

npy

phenylethanolamine

analysis

diagnostics

homovanillic

synthesis

Reaction

a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

1.14.16.2 tyrosine 3-monooxygenase

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Results	in table
66	Activating Compound
1004	AA Sequence
3	Application
1	CAS Registry Number
72	Cloned(Commentary)
64	Cofactor
4	Crystallization (Commentary)
3817	Disease/ Diagnostics
41	Expression
14	General Information
14	General Stability
18	IC50 Value
146	Inhibitors
16	kcat/KM [mM/s]
34	Ki Value [mM]
230	KM Value [mM]
26	Localization
34	Metals/Ions
52	Molecular Weight [Da]
123	Natural Substrates/ Products (Substrates)
260	Organism
14	Pathway
30	PDB ID
27	pH Optimum
3	pH Range
3	pH Stability
4	pI Value
39	Posttranslational Modification
125	Protein Variants
55	Purification (Commentary)
12	Reaction
4	Reaction Type
194	Reference
252	Source Tissue
54	Specific Activity [micromol/min/mg]
12	Storage Stability
290	Substrates and Products (Substrate)
37	Subunits
196	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
16	Temperature Stability [°C]
27	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 1.14.16.2 - tyrosine 3-monooxygenase

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Ca2+

Bos taurus

activates the enzyme via retinol induction of extracellular Ca2+ influx, the activation is completely blocked by EGTA

Cu2+

slightly activating

Fe2+

Iron

Mn2+

Portulaca grandiflora

activates

NaCl

activates

phosphate

Zn2+

0.13 mol per mol of subunit

438684