1.14.16.2: tyrosine 3-monooxygenase
This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.2
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1.14.16.2
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dopamine
-
dopaminergic
-
parkinsonism
-
nigra
-
striatum
-
catecholamine
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substantia
-
nerve
-
ventral
-
fiber
-
sympathetic
-
innervation
-
adrenal
-
noradrenergic
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neurotransmitter
-
6-hydroxydopamine
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ganglia
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th-positive
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catecholaminergic
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neuropeptide
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norepinephrine
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nigrostriatal
-
midbrain
-
monoamine
-
neurotrophic
-
compacta
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coeruleus
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hypothalamus
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tegmental
-
mesencephalic
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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l-dopa
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6-ohda
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neurochemical
-
accumbens
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noradrenaline
-
rostrally
-
dopac
-
apomorphine
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perikarya
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intrastriatal
-
beta-hydroxylase
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mptp-induced
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varicosity
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ventrolateral
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dopamine-beta-hydroxylase
-
preoptic
-
npy
-
phenylethanolamine
-
analysis
-
diagnostics
-
homovanillic
-
synthesis
- 1.14.16.2
- dopamine
-
dopaminergic
- parkinsonism
- nigra
- striatum
- catecholamine
-
substantia
- nerve
-
ventral
- fiber
-
sympathetic
-
innervation
- adrenal
-
noradrenergic
-
neurotransmitter
- 6-hydroxydopamine
- ganglia
-
th-positive
-
catecholaminergic
-
neuropeptide
- norepinephrine
-
nigrostriatal
- midbrain
-
monoamine
-
neurotrophic
- compacta
- coeruleus
- hypothalamus
- tegmental
-
mesencephalic
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- l-dopa
-
6-ohda
-
neurochemical
- accumbens
- noradrenaline
-
rostrally
-
dopac
- apomorphine
- perikarya
-
intrastriatal
- beta-hydroxylase
-
mptp-induced
-
varicosity
-
ventrolateral
- dopamine-beta-hydroxylase
-
preoptic
- npy
- phenylethanolamine
- analysis
- diagnostics
-
homovanillic
- synthesis
Reaction
Synonyms
CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase
ECTree
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Cofactor
Cofactor on EC 1.14.16.2 - tyrosine 3-monooxygenase
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(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
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i.e. BH4, complex regulation by the cofactor including both enzyme inactivation and conformational stabilization, competitive inhibition
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine
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strictly requirred
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine
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tetrahydrobiopterin
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tetrahydrobiopterin
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tetrahydrobiopterin
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binding of dopamine to the high-affinity site of the enzyme decreases Vmax and increases the Km for the cofactor tetrahydrobiopterin, while binding of dopamine to the low affinity site regulates tyrosine hydroxylase activity by increasing the Km for tetrahydrobiopterin