General Stability | Organism |
---|---|
phosphorylated enzyme is less stable than nonphosphorylated form | Rattus norvegicus |
phosphorylated enzyme is less stable than nonphosphorylated form | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Dopa | - |
Bos taurus | |
L-Dopa | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus | |
additional information | - |
additional information | - |
Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
peripheral noradrenergic neurons in superior cervical ganglion: MW 130000 Da | Rattus norvegicus |
additional information | - |
peripheral noradrenergic neurons in superior cervical ganglion: MW 130000 Da | Bos taurus |
additional information | - |
high molecular weight of brain enzyme is partly due to association with RNA. This makes it difficult to decide whether tyrosine hydroxylase molecules of different structure are present in the various regions of the brain, cell bodies of noradrenergic neurons: MW 200000 Da, substancia nigra and caudate nucleus, dopaminergic neurons: MW 65000 Da | Rattus norvegicus |
additional information | - |
high molecular weight of brain enzyme is partly due to association with RNA. This makes it difficult to decide whether tyrosine hydroxylase molecules of different structure are present in the various regions of the brain, cell bodies of noradrenergic neurons: MW 200000 Da, substancia nigra and caudate nucleus, dopaminergic neurons: MW 65000 Da | Bos taurus |
59000 | - |
4 * 59000, SDS-PAGE | Rattus norvegicus |
60000 | - |
4 * 60000, SDS-PAGE | Rattus norvegicus |
60000 | - |
4 * 60000, SDS-PAGE | Bos taurus |
62000 | - |
4 * 62000 | Rattus norvegicus |
260000 | - |
from adrenal medulla | Rattus norvegicus |
280000 | - |
- |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 | Rattus norvegicus | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | ? | - |
? | |
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 | Bos taurus | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | ? | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | Bos taurus | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Rattus norvegicus | - |
adrenal medulla | - |
Bos taurus | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | Rattus norvegicus | ? | - |
? | |
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | Bos taurus | ? | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Bos taurus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
L-tyrosine + tetrahydrobiopterin + O2 | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | Bos taurus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 62000 | Rattus norvegicus |
tetramer | 4 * 60000, SDS-PAGE | Rattus norvegicus |
tetramer | 4 * 60000, SDS-PAGE | Bos taurus |
tetramer | 4 * 59000, SDS-PAGE | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
half-life of activated, phosphorylated enzyme: 5 min, half-life of nonphosphorylated enzyme: 15 min | Rattus norvegicus |
50 | - |
half-life of activated, phosphorylated enzyme: 5 min, half-life of nonphosphorylated enzyme: 15 min | Bos taurus |