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1.1.1.61: 4-hydroxybutyrate dehydrogenase

This is an abbreviated version!
For detailed information about 4-hydroxybutyrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.61

Reaction

4-hydroxybutanoate
+
NAD+
=
succinate semialdehyde
+
NADH
+
H+

Synonyms

4HBD, gamma-hydroxybutyrate dehydrogenase, gbd, GHBDH, NAD-dependent 4-hydroxybutyrate dehydrogenase, PGN 0724 protein, succinate semialdehyde reductase, uncharacterized oxidoreductase YihU, yihU

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.61 4-hydroxybutyrate dehydrogenase

Reference

Reference on EC 1.1.1.61 - 4-hydroxybutyrate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nirenberg, M.W.; Jakoby, W.B.
Enzymatic utilization of gamma-hydroxybutyric acid
J. Biol. Chem.
235
954-960
1960
Pseudomonas sp.
Manually annotated by BRENDA team
Wolff, R.A.; Kenealy W.R.
Purification and characterization of the oxygen-sensitive 4-hydroxybutanoate dehydrogenase from Clostridium kluyveri
Protein Expr. Purif.
6
206-212
1995
Clostridium kluyveri
Manually annotated by BRENDA team
Breitkreuz, K.E.; Allan, W.L.; Van Cauwenberghe, O.R.; Jakobs, C.; Talibi, D.; Andre, B.; Shelp, B.J.
A novel gamma-hydroxybutyrate dehydrogenase: identification and expression of an Arabidopsis cDNA and potential role under oxygen deficiency
J. Biol. Chem.
278
41552-41556
2003
Arabidopsis thaliana (Q9LSV0), Arabidopsis thaliana
Manually annotated by BRENDA team
Bravo, D.T.; Harris, D.O.; Parsons, S.M.
Reliable, sensitive, rapid and quantitative enzyme-based assay for gamma-hydroxybutyric acid (GHB)
J. Forensic Sci.
49
379-387
2004
Cupriavidus necator
Manually annotated by BRENDA team
Saito, N.; Robert, M.; Kochi, H.; Matsuo, G.; Kakazu, Y.; Soga, T.; Tomita, M.
Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli
J. Biol. Chem.
284
16442-16451
2009
Escherichia coli, Escherichia coli (P0A9V8), Escherichia coli K12 BW25113 (P0A9V8)
Manually annotated by BRENDA team
Yoshida, Y.; Sato, M.; Nagano, K.; Hasegawa, Y.; Okamoto, T.; Yoshimura, F.
Production of 4-hydroxybutyrate from succinate semialdehyde in butyrate biosynthesis in Porphyromonas gingivalis
Biochim. Biophys. Acta
1850
2582-2591
2015
Porphyromonas gingivalis, Porphyromonas gingivalis ATCC 33277
Manually annotated by BRENDA team
Taxon, E.S.; Halbers, L.P.; Parsons, S.M.
Kinetics aspects of Gamma-hydroxybutyrate dehydrogenase
Biochim. Biophys. Acta Proteins Proteom.
1868
140376
2020
Cupriavidus necator (Q59104), Cupriavidus necator
Manually annotated by BRENDA team