1.1.1.61: 4-hydroxybutyrate dehydrogenase

This is an abbreviated version, for detailed information about 4-hydroxybutyrate dehydrogenase, go to the full flat file.

Reaction

4-hydroxybutanoate
+
NAD+
=
succinate semialdehyde
+
NADH
+
H+

Synonyms

4HBD, gamma-hydroxybutyrate dehydrogenase, GHBDH, PGN 0724 protein, succinate semialdehyde reductase, uncharacterized oxidoreductase YihU, yihU

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.61 4-hydroxybutyrate dehydrogenase

KM Value

KM Value on EC 1.1.1.61 - 4-hydroxybutyrate dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
3-hydroxypropane sulfonate
; in 100 mM Tris-HCl buffer (pH 8.8), at 37°C
0.055
4-hydroxybutanoate
-
-
102
4-hydroxybutyrate
-
14
ethanol
-
pH 8.5, 23°C
2.19 - 102
gamma-hydroxybutyrate
9
methylglyoxal
; in 100 mM Tris-HCl buffer (pH 8.8), at 37°C
0.15 - 0.41
NADH
0.15
succinate semialdehyde
-
with NADH as cosubstrate, at pH 8.0 and 37°C
0.56 - 4.3
Succinic semialdehyde