1.1.1.61: 4-hydroxybutyrate dehydrogenase

This is an abbreviated version, for detailed information about 4-hydroxybutyrate dehydrogenase, go to the full flat file.

Reaction

4-hydroxybutanoate
+
NAD+
=
succinate semialdehyde
+
NADH
+
H+

Synonyms

4HBD, gamma-hydroxybutyrate dehydrogenase, GHBDH, PGN 0724 protein, succinate semialdehyde reductase, uncharacterized oxidoreductase YihU, yihU

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.61 4-hydroxybutyrate dehydrogenase

General Information

General Information on EC 1.1.1.61 - 4-hydroxybutyrate dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
a yihU deletion mutant displays reduced tolerance to the cytotoxic effects of exogenous addition of succinic semialdehyde
metabolism
the enzyme is involved in the metabolism of succinic semialdehyde, and other potentially toxic intermediates that may accumulate under stress conditions in Escherichia coli