1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version, for detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, panG, Tk-KPR, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

KM Value

KM Value on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.13 - 2.04
(R)-pantoate
0.006 - 0.03
2-dehydropantoate
8.55
2-Keto-3-hydroxyisovalerate
-
-
8.7
2-oxoisovalerate
-
pH 7.5, 25C, recombinant enzyme
0.12 - 3.4
2-oxopantoate
0.075
3'-NADPH
-
pH 7.5, 25C, recombinant enzyme
3.8
3-methyl-2-oxo-n-valerate
-
pH 7.5, 25C, recombinant enzyme
0.036
alpha-NADPH
-
pH 7.5, 25C, recombinant enzyme
0.004
beta-NADPH
-
pH 7.5, 25C, recombinant enzyme
52.1
D-pantoic acid
-
pH 8.0
0.038 - 40
ketopantoate
0.4 - 0.742
ketopantoic acid
0.041
NAD+
recombinant enzyme, pH 6.4, 70C
0.003
NADH
recombinant enzyme, pH 6.4, 70C
0.007
NADP+
-
+/-0.002
0.00135 - 0.776
NADPH
0.26
Pantoate
-
+/-0.04
0.018
thio-NADPH
-
pH 7.5, 25C, recombinant enzyme
additional information
additional information
-