1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version, for detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, panG, Tk-KPR, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

Activating Compound

Activating Compound on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bromoethylamine
-
activation of enzyme from K176C mutant
ethylamine
-
activation of enzyme from K176A mutant
formate
-
E256A mutant activity greatly increased, twice as high at pH 7.2 as at pH 5.9
methylamine
-
activation of enzyme from K176A mutant
Propylamine
-
activation of enzyme from K176A mutant