1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version, for detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, panG, Tk-KPR, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

Inhibitors

Inhibitors on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-phospho-ADP-ribose
-
competitive
2'-phospho-AMP
-
competitive
ADP
-
competitive
AMP
-
competitive
ATP
-
noncompetitive
Barbital
-
9.0% at 1 mM
CoA
strong inhibition, competitive versus NADH, effect on enzyme kinetics, overview
D-pantoic acid
-
noncompetitive with ketopantoic acid at saturation level of NADPH, noncompetitive with NADPH at unsaturation level of ketopantoic acid
Diphenylhydantoin
-
22.6% at 1 mM
iodoacetate
-
sulfhydryl reagents, slightly inhibitory
NaAsO2
-
carbonyl reagent
NADP+
p-chloromercuribenzoate
-
sulfhydryl reagents, slightly inhibitory
Pantoate
-
noncompetitive versus ketopantoate and NADPH
phenylhydrazine
-
carbonyl reagent
phosphate
-
competitive
quercetin
-
12.0% at 0.1 mM
Semicarbazide
-
carbonyl reagent
additional information
-