1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version, for detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, panG, Tk-KPR, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

Engineering

Engineering on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E240A
-
site-directed mutagenesis, wild-type activity
E256D
-
wild-type activity
K176A/E256A
-
double mutant, no activity
K176C
-
wild-type activity
R31A
-
site-directed mutagenesis, altered steady-state kinetics of the mutant compared to the wild-type enzyme, overview
additional information