1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NAD+
=
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, dehydrogenase, 7alpha-hydroxy steroid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.159 7alpha-hydroxysteroid dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
-
ascorbic acid
-
-
chenodeoxycholate
-
substrate inhibition at concentration above 1 mM
CoCl2
CuCl2
diethyl dicarbonate
-
complete
FeCl3
glycochenodeoxycholate
-
substrate inhibition at concentration above 1 mM
HgCl2
iodoacetic acid
-
70% remaining activity at concentration 1 mM
N-bromosuccinimide
-
complete
o-phenanthroline
-
70% remaining acitvity at concentration 1 mM
p-chloromercuribenzoate
-
80% remaining activity at concentration 0.3 mM
p-hydroxymercuribenzoate
complete inhibition at 0.0075 mM
potassium oxalate
-
-
Sodium citrate
-
-
sodium lauryl sulfate
-
-
Sodium perchlorate
-
-
Sodium periodate
-
-
Sodium persulfate
-
-
taurochenodeoxycholate
-
substrate inhibition at concentration above 1 mM
Triton X-100
-
-