1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NAD+
=
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, dehydrogenase, 7alpha-hydroxy steroid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.159 7alpha-hydroxysteroid dehydrogenase

pH Optimum

pH Optimum on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.3
-
dehydrocholic acid reduction
6.5
NADH oxidation
7 - 9
-
NADP+-dependent activity
8.5 - 9
-
oxidation of 7alpha-hydroxy group
9 - 10
-
oxidation of cholic acid
9.4 - 9.6
-
-
9.5 - 10
-
NAD+-dependent activity
10
-
oxidation of cholic acid
10.5
-
oxidation of cholic acid
additional information
-
value for reduction of dehydrocholic acid below 5.2, not measurable due to insolubility of substrate