1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NAD+
=
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, dehydrogenase, 7alpha-hydroxy steroid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.159 7alpha-hydroxysteroid dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.035
-
cell extract
0.11
-
purified enzyme
0.32
-
purified recombinant enzyme, substrate methyl benzoylformate
1.1
-
crude extract
45
-
deoxycholic acid or lithocholic acid
70
-
purified native enzyme
332
-
NADP+, recombinant enzyme from Escherichia coli
351
purified enzyme, 37C
374
-
NADP+
400
-
7,12-diketolithocholic acid, NADH
1600
-
cholic acid, NAD+
1700
-
12-ketolithocholic acid, NAD+
2348
-
taurocholic acid
2900
-
dehydrocholic acid, NADH
2916
-
glycocholic acid
3486
-
cholic acid
3743
-
taurochenodeoxycholic acid
3856
-
glycochenodeoxycholic acid
4164
-
chenodeoxycholic acid
additional information