1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NAD+
=
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, dehydrogenase, 7alpha-hydroxy steroid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.159 7alpha-hydroxysteroid dehydrogenase

KM Value

KM Value on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.38
12-ketolithocholic acid
-
-
0.32 - 0.34
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoic acid
-
-
0.32 - 0.34
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl glycine
-
-
0.32 - 0.34
3alpha,7alpha,12alpha-trihydroxycholanoyl taurine
-
-
0.1
3alpha,7alpha-dihydroxy-5beta-cholanoic acid
-
-
0.1
3alpha,7alpha-Dihydroxy-5beta-cholanoyl glycine
-
-
0.1
3alpha,7alpha-dihydroxy-5beta-cholanoyl taurine
-
-
0.99
7,12-Diketolithocholic acid
-
-
0.0065 - 0.43
chenodeoxycholic acid
0.09 - 1.2
cholic acid
0.7
Dehydrocholic acid
-
-
0.085
glycochenodeoxycholic acid
-
-
1 - 1.25
glycocholic acid
0.15 - 0.709
NAD+
0.25 - 1.3
NADH
0.19 - 0.24
taurochenodeoxycholic acid
1 - 2
taurocholic acid