Reference on EC 6.1.1.2 - tryptophan-tRNA ligase and Organism(s) Homo sapiens and UniProt Accession P23381
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kisselev, L.L.
Mammalian tryptophanyl-tRNA synthetases
Biochimie
75
1027-1039
1993
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Mammalia, Mus musculus, Primates, Rattus norvegicus, Rodentia, Ruminantia
Ewalt, K.L.; Schimmel, P.
Activation of angiogenic signaling pathways by two human tRNA synthetases
Biochemistry
41
13344-13349
2002
Homo sapiens
Paley, E.L.
Tryptamine-mediated stabilization of tryptophanyl-tRNA synthetase in human cervical carcinoma cell line
Cancer Lett.
137
1-7
1999
Homo sapiens
Jorgensen, R.; Sogaard, T.M.; Rossing, A.B.; Martensen, P.M.; Justesen, J.
Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase
J. Biol. Chem.
275
16820-16826
2000
Homo sapiens (Q9UGM6), Homo sapiens
Yu, Y.; Liu, Y.; Shen, N.; Xu, X.; Xu, F.; Jia, J.; Jin, Y.; Arnold, E.; Ding, J.
Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
J. Biol. Chem.
279
8378-8388
2004
Homo sapiens (P23381), Homo sapiens
Ivanova, Y.L.; Cherni, N.E.; Narovlyanskii, A.N.; Amchenkova, A.M.; Turpaev, K.T.; Popenko, V.I.
Distribution of tryptophanyl-tRNA synthetase in interferon-treated human monocytes
Mol. Biol.
32
736-742
1998
Homo sapiens
-
Liu, J.; Shue, E.; Ewalt, K.L.; Schimmel, P.
A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase
Nucleic Acids Res.
32
719-727
2004
Homo sapiens
Yang, X.L.; Otero, F.J.; Skene, R.J.; McRee, D.E.; Schimmel, P.; de Pouplana, L.R.
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc. Natl. Acad. Sci. USA
100
15376-15380
2003
Homo sapiens (P23381), Homo sapiens
Xu, F.; Jia, J.; Jin, Y.; Wang, D.T.
High-level expression and single-step purification of human tryptophanyl-tRNA synthetase
Protein Expr. Purif.
23
296-300
2001
Homo sapiens
Wakasugi, K.; Nakano, T.; Morishima, I.
Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase
Biochemistry
44
225-232
2005
Homo sapiens
Boasso, A.; Herbeuval, J.P.; Hardy, A.W.; Winkler, C.; Shearer, G.M.
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
Blood
105
1574-1581
2005
Homo sapiens
Tzima, E.; Reader, J.S.; Irani-Tehrani, M.; Ewalt, K.L.; Schwartz, M.A.; Schimmel, P.
VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
J. Biol. Chem.
280
2405-2408
2005
Homo sapiens
Kise, Y.; Lee, S.W.; Park, S.G.; Fukai, S.; Sengoku, T.; Ishii, R.; Yokoyama, S.; Kim, S.; Nureki, O.
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Nat. Struct. Mol. Biol.
11
149-156
2004
Homo sapiens (P23381), Homo sapiens
Yang, X.L.; Schimmel, P.; Ewalt, K.L.
Relationship of two human tRNA synthetases used in cell signaling
Trends Biochem. Sci.
29
250-256
2004
Homo sapiens (P23381), Homo sapiens
Wakasugi, K.
Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity
Biochemistry
46
11291-11298
2007
Homo sapiens (P23381), Homo sapiens
Yang, X.L.; Otero, F.J.; Ewalt, K.L.; Liu, J.; Swairjo, M.A.; Koehrer, C.; RajBhandary, U.L.; Skene, R.J.; McRee, D.E.; Schimmel, P.
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis
EMBO J.
25
2919-2929
2006
Homo sapiens (P23381), Homo sapiens
Paley, E.L.; Denisova, G.; Sokolova, O.; Posternak, N.; Wang, X.; Brownell, A.L.
Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models
Neuromolecular Med.
9
55-82
2007
Homo sapiens, Mus musculus, Mus musculus BALB/c
Shen, N.; Guo, L.; Yang, B.; Jin, Y.; Ding, J.
Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity
Nucleic Acids Res.
34
3246-3258
2006
Homo sapiens (P23381), Homo sapiens
Guo, L.T.; Chen, X.L.; Zhao, B.T.; Shi, Y.; Li, W.; Xue, H.; Jin, Y.X.
Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311
Nucleic Acids Res.
35
5934-5943
2007
Homo sapiens (P23381), Homo sapiens
Shen, N.; Zhou, M.; Yang, B.; Yu, Y.; Dong, X.; Ding, J.
Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res.
36
1288-1299
2008
Homo sapiens (P23381), Homo sapiens
Wakasugi, K.
An exposed cysteine residue of human angiostatic mini tryptophanyl-tRNA synthetase
Biochemistry
49
3156-3160
2010
Homo sapiens (P23381), Homo sapiens
Ghanipour, A.; Jirstroem, K.; Ponten, F.; Glimelius, B.; Pahlman, L.; Birgisson, H.
The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer
Cancer Epidemiol. Biomarkers Prev.
18
2949-2956
2009
Homo sapiens
Wakasugi, K.
Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases
FEBS Lett.
584
229-232
2010
Bos taurus, Mus musculus, Homo sapiens (P23381), Homo sapiens
Hansia, P.; Ghosh, A.; Vishveshwara, S.
Ligand dependent intra and inter subunit communication in human tryptophanyl tRNA synthetase as deduced from the dynamics of structure networks
Mol. Biosyst.
5
1860-1872
2009
Homo sapiens (P23381), Homo sapiens
Hjelm, B.; Fernandez, C.D.; Loefblom, J.; Stahl, S.; Johannesson, H.; Rockberg, J.; Uhlen, M.
Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase
N. Biotechnol.
27
129-137
2010
Homo sapiens (P23381), Homo sapiens
Zhou, Q.; Kapoor, M.; Guo, M.; Belani, R.; Xu, X.; Kiosses, W.B.; Hanan, M.; Park, C.; Armour, E.; Do, M.H.; Nangle, L.A.; Schimmel, P.; Yang, X.L.
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
Nat. Struct. Mol. Biol.
17
57-61
2010
Homo sapiens (P23381), Homo sapiens
Bhattacharyya, M.; Ghosh, A.; Hansia, P.; Vishveshwara, S.
Allostery and conformational free energy changes in human tryptophanyl-tRNA synthetase from essential dynamics and structure networks
Proteins
78
506-517
2010
Homo sapiens (P23381), Homo sapiens
Ahn, Y.H.; Park, S.; Choi, J.J.; Park, B.K.; Rhee, K.H.; Kang, E.; Ahn, S.; Lee, C.H.; Lee, J.S.; Inn, K.S.; Cho, M.L.; Park, S.H.; Park, K.; Park, H.J.; Lee, J.H.; Park, J.W.; Kwon, N.H.; Shim, H.; Han, B.W.; Kim, P.; Lee, J.Y.; Jeon, Y.; Huh, J.W.; Jin, M.; Kim, S.
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
Nat. Microbiol.
2
16191
2016
Homo sapiens (P23381), Homo sapiens, Mus musculus (P32921), Mus musculus, Mus musculus C57BL/6 (P32921)
Lee, C.W.; Chang, K.P.; Chen, Y.Y.; Liang, Y.; Hsueh, C.; Yu, J.S.; Chang, Y.S.; Yu, C.J.
Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness
Oncotarget
6
21979-21992
2015
Homo sapiens
Nakamoto, T.; Miyanokoshi, M.; Tanaka, T.; Wakasugi, K.
Identification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution
Sci. Rep.
6
24750
2016
Bos taurus (P17248), Bos taurus, Homo sapiens (P23381), Homo sapiens, Danio rerio (Q6PBS3), Danio rerio, Arabidopsis thaliana (Q9SR15)
