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Literature summary for 6.1.1.2 extracted from

  • Ivanova, Y.L.; Cherni, N.E.; Narovlyanskii, A.N.; Amchenkova, A.M.; Turpaev, K.T.; Popenko, V.I.
    Distribution of tryptophanyl-tRNA synthetase in interferon-treated human monocytes (1998), Mol. Biol., 32, 736-742.
No PubMed abstract available
Search for more literature for 6.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
interferons interferons alpha, beta, and gamma, induction of accumulation of the enzyme, organelle-specific, the highest content is observed in the cytoplasm, followd by the nucleolus and the nucleus, the latter with a low enzyme content Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm especially the periphery Homo sapiens 5737
-
additional information interferons alpha, beta, and gamma induce organelle-specific accumulation of the enzyme, the highest content is observed in the cytoplasm, followd by the nucleolus and the nucleus, the latter with a low enzyme content Homo sapiens
-
-
nucleolus
-
 Homo sapiens 5730
-
nucleus low content Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
J-96 cell monocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Synonyms

Synonyms Comment Organism
Tryptophanyl-tRNA synthase
-
 Homo sapiens
WRS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens