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Literature summary for 6.1.1.2 extracted from

  • Liu, J.; Shue, E.; Ewalt, K.L.; Schimmel, P.
    A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase (2004), Nucleic Acids Res., 32, 719-727.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
interferon gamma strongly stimulates and regulates the expression of the enzyme isoforms via 2 specific interferon-gamma-sensitive promoters that are additionally regulated by the interferon regulatory factor 1 Homo sapiens
interferon regulatory factor 1 stimulates and regulates the enzyme isoforms expression via 2 specific interferon-gamma-sensitive promoters that are additionally regulated by the interferon gamma Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
determination of regulation involved promoter sequences Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens full-length and mini enzyme isoforms, enzyme expression is regulated by a dual system of interferon gamma and interferon regulatory factor 1 via 2 specific tandem promoters leading to alternative splicing AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
additional information Homo sapiens mini isozyme specifically shows anti-proliferative and anti-angiogenic activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 2 enzyme isoforms by alternative splicing in vivo, i.e. full-length and mini enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell umbilical vein Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
umbilical vein endothelial cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp full-length and mini enzyme isoforms Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
ATP + L-tryptophan + tRNATrp full-length and mini enzyme isoforms, enzyme expression is regulated by a dual system of interferon gamma and interferon regulatory factor 1 via 2 specific tandem promoters leading to alternative splicing Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
additional information mini isozyme specifically shows anti-proliferative and anti-angiogenic activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TrpRS
-
 Homo sapiens
Tryptophanyl-tRNA synthase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens