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Literature summary for 6.1.1.2 extracted from

  • Zhou, Q.; Kapoor, M.; Guo, M.; Belani, R.; Xu, X.; Kiosses, W.B.; Hanan, M.; Park, C.; Armour, E.; Do, M.H.; Nangle, L.A.; Schimmel, P.; Yang, X.L.
    Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality (2010), Nat. Struct. Mol. Biol., 17, 57-61.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.2

Protein Variants

Protein Variants Comment Organism
A310W T2-TrpRS mutant, AMP pocket is blocked, angiostatic activity involves the tryptophan and adenosine pockets Homo sapiens
G161W T2-TrpRS mutant, tryptophan pocket is blocked by the bulky indole side chain of the tryptophan introduced at position 161, angiostatic activity involves the tryptophan and adenosine pockets Homo sapiens
G172M T2-TrpRS mutant, AMP pocket is blocked, angiostatic activity involves the tryptophan and adenosine pockets Homo sapiens
Y159A/Q194A T2-TrpRS mutant, enzyme specific recognition of the indole nitrogen of tryptophan is disrupted, angiostatic activity involves the tryptophan and adenosine pockets Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophyl-tRNATrp
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23381
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophyl-tRNATrp
-
 ?
additional information vascular endothelial cadherins tryptophan side chains fit into the tryptophan-specific active site of the synthetase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
T2-TrpRS composed of residues 94-471 of TrpRS Homo sapiens
TrpRS
-
 Homo sapiens
Tryptophanyl-tRNA synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens