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Literature summary for 6.1.1.2 extracted from

  • Boasso, A.; Herbeuval, J.P.; Hardy, A.W.; Winkler, C.; Shearer, G.M.
    Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells (2005), Blood, 105, 1574-1581.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens interferon-gamma-inducible enzyme. Exposure to soluble cytotoxic T lymphocyte antigen-4 induces increased expression of tryptophanyl-tRNA synthetase in unseparated peripheral blood mononuclear cells, as well as in monocyte-derived mature dentritic cells. CD4+ cells and CD8+ cells isolated from peripheral blood mononuclear cells treated with soluble cytotoxic T lymphocyte antigen-4 show increased tryptophanyl-tRNA synthetase compared with untreated cells. Possibility that tryptophanyl-tRNA synthetase may be involved in an important mechanism regulating immune response ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell monocyte-derived mature Homo sapiens
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peripheral blood mononuclear cell CD4+ cell, CD8+ cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information interferon-gamma-inducible enzyme. Exposure to soluble cytotoxic T lymphocyte antigen-4 induces increased expression of tryptophanyl-tRNA synthetase in unseparated peripheral blood mononuclear cells, as well as in monocyte-derived mature dentritic cells. CD4+ cells and CD8+ cells isolated from peripheral blood mononuclear cells treated with soluble cytotoxic T lymphocyte antigen-4 show increased tryptophanyl-tRNA synthetase compared with untreated cells. Possibility that tryptophanyl-tRNA synthetase may be involved in an important mechanism regulating immune response Homo sapiens ?
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