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2,3-dimethyl-cis,cis-muconate
2,3-dimethylmuconolactone
-
-
-
?
2,4-dichloro-cis,cis-muconate
?
2,4-dimethyl-cis,cis-muconate
2,4-dimethylmuconolactone
-
-
-
?
2,5-dihydro-5-oxofuran-2-acetate
cis,cis-hexadienedioate
-
-
-
-
?
2-chloro-cis,cis-muconate
(+)-2-chloromuconolactone + (+)-5-chloromuconolactone
-
-
mutant enzymes I54V and I54V/Y59W form 5-chloromuconolactone almost exclusively. Mutant enzymes F329I and Y59W form 2-chloromuconolactone as the main product. Mutant enzyme A271S hehaves similar to wild-type enzyme
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
2-Chloro-cis,cis-muconate
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
2-Methyl-cis,cis-muconate
?
3-Bromo-cis,cis-muconate
?
-
at 9% of the activity relative to 3-methyl-cis,cis-muconate
-
-
?
3-chloro-cis,cis-muconate
4-chloro-muconolactone
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
3-chloro-cis,cis-muconate
?
-
-
?
3-chloro-cis,cis-muconate
cis-dienelactone + protoanemonin + Cl- + H2O + CO2
3-chloro-cis,cis-muconate
protoanemonin + ?
-
-
formed by wild-type enzyme and mutant enzymes I54V, A271S, K276N, F329I, L333V, I54V/F329I
?
3-chloromuconate
cis-dienelactone + protoanemonin
the highest turnover rate, 10fold higher than with 3-methylmuconate, is observed with 3-chloromuconate
-
-
?
3-ethyl-cis,cis-muconate
4-ethylmuconolactone
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
3-Fluoro-cis,cis-muconate
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
3-Methyl-cis,cis-muconate
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
cis,cis-hexadienedioate
2,5-dihydro-5-oxofuran-2-acetate
cis,cis-muconate
(+)-(4S)-muconolactone
-
syn-cycloisomerization
-
-
?
cis,cis-Muconate
(+)-Muconolactone
cis,cis-muconate
(4S)-muconolactone
cis,cis-muconate
muconolactone
3-chloro-cis,cis-muconate
additional information
-
2,4-dichloro-cis,cis-muconate
?
-
-
-
?
2,4-dichloro-cis,cis-muconate
?
-
-
-
?
2,4-dichloro-cis,cis-muconate
?
-
-
?
2,4-dichloro-cis,cis-muconate
?
-
-
-
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
-
-
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
-
-
-
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
-
-
-
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
-
-
-
-
?
2-chloro-cis,cis-muconate
5-chloromuconolactone + 2-chloromuconolactone
-
-
-
-
?
2-Chloro-cis,cis-muconate
?
-
-
-
?
2-Chloro-cis,cis-muconate
?
-
0.8% of the activity relative to cis,cis-muconate
-
-
?
2-Chloro-cis,cis-muconate
?
-
0.8% of the activity relative to cis,cis-muconate
-
-
?
2-Chloro-cis,cis-muconate
?
-
-
-
-
?
2-Chloro-cis,cis-muconate
?
-
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
?
2-methyl-cis,cis-muconate
2-methylmuconolactone
-
-
-
?
2-Methyl-cis,cis-muconate
?
-
-
-
?
2-Methyl-cis,cis-muconate
?
-
at 80% of the activity relative to cis,cis-muconate
-
-
?
2-Methyl-cis,cis-muconate
?
-
at 80% of the activity relative to cis,cis-muconate
-
-
?
2-Methyl-cis,cis-muconate
?
-
-
?
2-Methyl-cis,cis-muconate
?
-
90% of the activity relative to cis,cis-muconate
-
-
?
2-Methyl-cis,cis-muconate
?
-
90% of the activity relative to cis,cis-muconate
-
-
?
2-Methyl-cis,cis-muconate
?
-
-
-
-
?
2-Methyl-cis,cis-muconate
?
-
at 6.1% of the activity relative to cis,cis-muconate
-
-
?
2-Methyl-cis,cis-muconate
?
-
-
-
-
?
2-Methyl-cis,cis-muconate
?
-
at 6.1% of the activity relative to cis,cis-muconate
-
-
?
2-methylmuconate
?
-
-
-
?
2-methylmuconate
?
-
27% activity compared to cis,cis-muconate
-
-
?
2-methylmuconate
?
-
27% activity compared to cis,cis-muconate
-
-
?
3-chloro-cis,cis-muconate
4-chloro-muconolactone
-
-
unstable
-
?
3-chloro-cis,cis-muconate
4-chloro-muconolactone
-
-
unstable
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
at 11% of the activity relative to 3-methyl-cis,cis-muconate
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
7.1% of the activity relative to cis,cis-muconate
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
7.1% of the activity relative to cis,cis-muconate
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
-
-
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
dehalogenation is not catalyzed
?
3-Chloro-cis,cis-muconate
5-Chloromuconolactone
-
-
dehalogenation is not catalyzed
?
3-chloro-cis,cis-muconate
cis-dienelactone + protoanemonin + Cl- + H2O + CO2
-
in vitro activity
product ratio is 76:24, protoanemonin is antibiotically active
-
?
3-chloro-cis,cis-muconate
cis-dienelactone + protoanemonin + Cl- + H2O + CO2
-
in vitro activity
product ratio is 76:24, protoanemonin is antibiotically active
-
?
3-chloromuconate
?
-
9% activity compared to cis,cis-muconate
-
-
?
3-chloromuconate
?
-
9% activity compared to cis,cis-muconate
-
-
?
3-ethyl-cis,cis-muconate
4-ethylmuconolactone
-
-
-
-
?
3-ethyl-cis,cis-muconate
4-ethylmuconolactone
-
-
-
-
?
3-ethyl-cis,cis-muconate
4-ethylmuconolactone
-
-
-
?
3-ethyl-cis,cis-muconate
4-ethylmuconolactone
-
-
-
?
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
-
-
-
?
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
-
-
-
?
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
-
-
-
?
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
-
-
-
?
3-Fluoro-cis,cis-muconate
(+)-4-Fluoromuconolactone
-
at 17% of the activity relative to 3-methyl-cis,cis-muconate
-
-
?
3-Fluoro-cis,cis-muconate
?
-
-
-
?
3-Fluoro-cis,cis-muconate
?
-
-
-
?
3-Fluoro-cis,cis-muconate
?
-
-
-
?
3-Fluoro-cis,cis-muconate
?
-
-
?
3-Fluoro-cis,cis-muconate
?
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
?
3-methyl-cis,cis-muconate
4-methylmuconolactone
-
-
-
?
3-Methyl-cis,cis-muconate
?
-
-
-
?
3-Methyl-cis,cis-muconate
?
-
enzyme of the beta-ketoadipate pathway that also functions in the reaction sequence for converting 3-methyl-cis,cis-muconate
-
-
?
3-Methyl-cis,cis-muconate
?
-
-
-
?
3-Methyl-cis,cis-muconate
?
-
-
?
3-Methyl-cis,cis-muconate
?
-
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
-
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
11.7% of the activity relative to cis,cis-muconate
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
11.7% of the activity relative to cis,cis-muconate
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
-
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
at 5.6% of the activity relative to cis,cis-muconate
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
-
-
-
?
3-Methyl-cis,cis-muconate
beta-Methylmuconolactone
-
at 5.6% of the activity relative to cis,cis-muconate
-
-
?
3-methylmuconate
?
-
-
-
?
3-methylmuconate
?
-
26% activity compared to cis,cis-muconate
-
-
?
3-methylmuconate
?
-
26% activity compared to cis,cis-muconate
-
-
?
cis,cis-hexadienedioate
2,5-dihydro-5-oxofuran-2-acetate
-
conversion of cis,cis-muconate to muconolactone, two proximal Lys residues exist in the active sites, which can potentially lead, via a single intermediate form, to the formation of either the syn- or anti-products. The enzyme from Mycobacterium smegmatis forms a syn-product, overview
-
-
r
cis,cis-hexadienedioate
2,5-dihydro-5-oxofuran-2-acetate
-
conversion of cis,cis-muconate to muconolactone, two proximal Lys residues exist in the active sites, which can potentially lead, via a single intermediate form, to the formation of either the syn- or anti-products. The enzyme from Pseudomonas fluorescens forms an anti-product, overview
-
-
r
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
i.e. 5-oxo-2,5-dihydrofuran-2-acetate, , (4S)-muconolactone
?
cis,cis-Muconate
(+)-Muconolactone
-
no activity against trans-trans-muconate
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
2970, 2972, 3636, 3639, 3643, 3645, 3649, 3650, 3651, 3652, 3653, 390694 -
-
?
cis,cis-Muconate
(+)-Muconolactone
-
i.e. cis,cis-2,4-hexadiendioate, , r
-
?
cis,cis-Muconate
(+)-Muconolactone
-
i.e. cis,cis-2,4-hexadiendioate, , r
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-Muconate
(+)-Muconolactone
-
-
-
-
?
cis,cis-muconate
(4S)-muconolactone
syn-cycloisomerization
-
-
?
cis,cis-muconate
(4S)-muconolactone
-
-
-
-
?
cis,cis-muconate
(4S)-muconolactone
-
-
-
?
cis,cis-muconate
(4S)-muconolactone
-
-
-
?
cis,cis-Muconate
?
-
inducible by benzoate
-
-
?
cis,cis-Muconate
?
-
inducible enzyme
-
-
?
cis,cis-Muconate
?
-
enzyme of the beta-ketoadipate pathway
-
-
?
cis,cis-Muconate
?
-
the enzyme plays a key role in the beta-ketoadipate pathway of benzoate degradation
-
-
?
cis,cis-Muconate
?
-
enzyme of the beta-ketoadipate pathway
-
-
?
cis,cis-Muconate
?
-
enzyme of the benzoate catabolism
-
-
?
cis,cis-Muconate
?
-
enzyme of the beta-ketoadipate pathway
-
-
?
cis,cis-Muconate
?
-
enzyme of the benzoate catabolism
-
-
?
cis,cis-Muconate
?
-
catalyzes the second step of the beta-ketoadipate pathway
-
-
?
cis,cis-Muconate
?
-
catalyzes the second step of the beta-ketoadipate pathway
-
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
the enzyme plays a crucial role in the bacterial degradation of aromatic compounds by converting cis,cis-muconate, the product of catechol ring cleavage to (4S)-muconolactone
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
different inducible production of MC I and MC II suggest that two catechol branches involved in the beta-ketoadipate pathway function in Frateuria sp. ANA-18
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
different inducible production of MC I and MC II suggest that two catechol branches involved in the beta-ketoadipate pathway function in Frateuria sp. ANA-18
-
?
cis,cis-muconate
muconolactone
-
-
-
-
?
cis,cis-muconate
muconolactone
-
-
-
-
?
cis,cis-muconate
muconolactone
-
-
-
-
?
cis,cis-muconate
muconolactone
-
i.e. cis,cis-hexadienedioate or (2Z,4Z)-hexa-2,4-dienedioate, in vitro activity
i.e. (2,5-dihydro-5-oxofuran-2-yl)acetate
-
?
cis,cis-muconate
muconolactone
-
-
-
-
?
cis,cis-muconate
muconolactone
-
i.e. cis,cis-hexadienedioate or (2Z,4Z)-hexa-2,4-dienedioate, in vitro activity
i.e. (2,5-dihydro-5-oxofuran-2-yl)acetate
-
?
cis,cis-muconate
muconolactone
-
-
-
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
-
?
cis,cis-muconate
muconolactone
-
the enzyme plays a crucial role in the bacterial degradation of aromatic compounds by converting cis,cis-muconate, the product of catechol ring cleavage to (4S)-muconolactone
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
-
the enzyme plays a crucial role in the bacterial degradation of aromatic compounds by converting cis,cis-muconate, the product of catechol ring cleavage to (4S)-muconolactone
-
?
cis,cis-muconate
muconolactone
-
-
-
?
cis,cis-muconate
muconolactone
5.5.1.1 Muconate cycloisomerase
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