EC Number |
Metals/Ions |
Reference |
---|
5.5.1.1 | Co2+ |
6% of the activity with Mn2+, enzyme form MC II |
650594 |
5.5.1.1 | Co2+ |
is the best metal ion activator |
3642 |
5.5.1.1 | Fe2+ |
0.4% of the activity with Mn2+, enzyme form MC II |
650594 |
5.5.1.1 | Mg2+ |
28% of the activity with Mn2+, enzyme form MC I. 17% of the activity with Mn2+, enzyme form MC II |
650594 |
5.5.1.1 | Mg2+ |
56% of the activity with Mn2+ |
661780 |
5.5.1.1 | Mg2+ |
can partially replace Mg2+ |
2972 |
5.5.1.1 | Mg2+ |
Mg2+ binds deep within a non-solvent exposed cavity, coordinated by 2 aspartate and 1 glutamic acid residues, a single water molecule and the substrate, in a distorted octahedral form. The carboxylate of cis,cis-muconate binds across the Mg2+ ion in conformations that display mirror-like symmetry in the two different proteins |
715976 |
5.5.1.1 | Mn2+ |
activates to a lower extent than Co2+ |
3642 |
5.5.1.1 | Mn2+ |
active enzyme contains Mn2+ |
653804 |
5.5.1.1 | Mn2+ |
divalent metal ion is required, Mn2+ is preferred |
3649 |