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Information on EC 5.3.2.6 - 2-hydroxymuconate tautomerase

for references in articles please use BRENDA:EC5.3.2.6

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IUBMB Comments

Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex-3-enedioate by the enzyme . Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme [1,2] but later shown to be produced non-enzymatically .

The enzyme appears in viruses and cellular organisms

Synonyms
4-oxalocrotonate tautomerase, afdmpi, hpdmpi, sar1376, 2-hydroxymuconate tautomerase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
show the reaction diagram