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Literature summary for 5.3.2.6 extracted from

  • Diemen, P.M.V.; Leneghan, D.B.; Brian, I.J.; Miura, K.; Long, C.A.; Milicic, A.; Biswas, S.; Rollier, C.S.; Wyllie, D.H.
    The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens (2017), Sci. Rep., 7, 1745 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
P1A inactive Staphylococcus aureus
R35A the mutation disrupts catalysis and impairs protein multimerisation Staphylococcus aureus
R35Q the mutation disrupts catalysis and impairs protein multimerisation Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate Staphylococcus aureus
-
(3E)-2-oxohex-3-enedioate
-
r
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate Staphylococcus aureus MRSA252
-
(3E)-2-oxohex-3-enedioate
-
r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q6GH41
-
-
Staphylococcus aureus MRSA252 Q6GH41
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate
-
Staphylococcus aureus (3E)-2-oxohex-3-enedioate
-
r
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate
-
Staphylococcus aureus MRSA252 (3E)-2-oxohex-3-enedioate
-
r

Synonyms

Synonyms Comment Organism
4-OT
-
Staphylococcus aureus
4-oxalocrotonate tautomerase
-
Staphylococcus aureus
SAR1376
-
Staphylococcus aureus