We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand 2-oxo-3-hexenedioate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C6 H6 O5
2-oxo-3-hexenedioate
QTHJXLFFFTVYJC-OWOJBTEDSA-N
(3E)-2-oxohex-3-enedioate, 2-oxo-3(E)-hexenedioate, 2-oxo-3,4-hexenedioate, 2-oxo-3-(E)-hexenedioate, 2-oxo-3-trans-hexenedioate
Related pathways
MetaCyc
2,2'-dihydroxybiphenyl degradation, 2,3-dihydroxybenzoate degradation, 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate, 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA, 2-aminophenol degradation
, 2-nitrobenzoate degradation I, 3-chlorocatechol degradation III (meta pathway), 4-amino-3-hydroxybenzoate degradation, catechol degradation to 2-hydroxypentadienoate II, orthanilate degradation, protocatechuate degradation III (para-cleavage pathway) more
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (5 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
-
-
2-oxo-4(E)-hexenedioate = 2-oxo-3(E)-hexenedioate
-
-
2-hydroxy-2,4-hexadienedioate = 2-oxo-3-hexenedioate
-
-
2-hydroxymuconate = 2-oxo-3-hexenedioate
-
-
2-oxo-4-hexenedioate = 2-oxo-3-hexenedioate
-
-
Substrate in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(3E)-2-oxohex-3-enedioate = 2-oxopent-4-enoate + CO2
-
2-oxo-3-hexenedioate = 2-oxopent-4-enoate + CO2
-
2-oxo-3-hexenedioate = 2-oxo-3-trans-hexenedioate
-
Product in Enzyme-catalyzed Reactions (9 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3
-
-
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
-
-
2-oxo-4(E)-hexenedioate = 2-oxo-3(E)-hexenedioate
-
-
2-hydroxy-2,4-hexadienedioate = 2-oxo-3,4-hexenedioate
-
-
2-hydroxymuconate = 2-oxo-3-(E)-hexenedioate
-
-
2-hydroxy-2,4-hexadienedioate = 2-oxo-3-hexenedioate
-
-
2-hydroxymuconate = 2-oxo-3-hexenedioate
-
-
2-oxo-4-hexenedioate = 2-oxo-3-hexenedioate
-
-
2-oxo-3-hexenedioate = 2-oxo-3-trans-hexenedioate
-
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (7 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM Value (7 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
References & Links Literature References (4)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase
2000
Stanley, T.M.; Johnson, W.H., Jr.; Burks, E.A.; Whitman, C.P.; Hwang, C.C.; Cook, P.F.
Biochemistry
39
718-726
-
Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol
1991
Whitman, C.; Aird, B.; Gillespie, W.; Stolowich, N.
J. Am. Chem. Soc.
113
3154-3162
Crystal structures of apo and liganded 4-oxalocrotonate decarboxylase uncover a structural basis for the metal-assisted decarboxylation of a vinylogous beta-keto acid
2016
Guimaraes, S.L.; Coitinho, J.B.; Costa, D.M.; Araujo, S.S.; Whitman, C.P.; Nagem, R.A.
Biochemistry
55
2632-2645
Crystal structures of apo and liganded 4-oxalocrotonate decarboxylase uncover a structural basis for the metal-assisted decarboxylation of a vinylogous beta-keto acid
2016
Guimaraes, S.L.; Coitinho, J.B.; Costa, D.M.; Araujo, S.S.; Whitman, C.P.; Nagem, R.A.
Biochemistry
55
2632-2645
Links to other databases for 2-oxo-3-hexenedioate
more
Show all BRENDA pathways known for 2-oxo-3-hexenedioate
close all tables 
open all tables
top
