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Information on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase

for references in articles please use BRENDA:EC3.6.1.62
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IUBMB Comments
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) . The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
D10 decapping enzyme, D10 protein, D9 protein, Dcp2, decapping nudix hydrolase, H29K, hDcp2, hNUDT16, Nudt16, X29, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O = N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
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