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Literature summary for 3.6.1.62 extracted from

  • Grudzien-Nogalska, E.; Jiao, X.; Song, M.G.; Hart, R.P.; Kiledjian, M.
    Nudt3 is an mRNA decapping enzyme that modulates cell migration (2016), RNA, 22, 773-781 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.62

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O Homo sapiens
-
 N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O
-
 Homo sapiens N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
-
 ?

Synonyms

Synonyms Comment Organism
mRNA decapping enzyme
-
 Homo sapiens
NUDT3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction reduction of enzyme protein levels in MCF-7 cells promotes increased cell migration and corresponding enhanced filopodia extensions. Enzyme depletion elevates RNA and protein expression of integrin beta6 and fibronectin, which in turn increases MCF-7 cell motility Homo sapiens
physiological function the enzyme is a modulator of MCF-7 breast cancer cell migration Homo sapiens