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Literature summary for 3.6.1.62 extracted from

  • Grzela, R.; Nasilowska, K.; Lukaszewicz, M.; Tyras, M.; Stepinski, J.; Jankowska-Anyszka, M.; Bojarska, E.; Darzynkiewicz, E.
    Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides (2018), RNA, 24, 633-642 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.62

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta 2 (DE3) cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O
-
 Homo sapiens N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
-
 ?
ApppG + H2O unmethylated dinucleotide ApppG is hydrolyzed by the enzyme with greater efficiency than m7GpppG (94.32% hydrolysis after 100 min) Homo sapiens ?
-
 ?
GpppA-[16nt mRNA] + H2O unmethylated oligonucleotide GpppA-16nt is hydrolyzed by the enzyme with greater efficiency than m7GpppG-[16nt RNA] (89.75% hydrolysis after 60 min) Homo sapiens ?
-
 ?
GpppG + H2O unmethylated dinucleotide GpppG is hydrolyzed by the enzyme with greater efficiency than m7GpppG (98.79% hydrolysis after 40 min) Homo sapiens ?
-
 ?
GpppG-[16nt mRNA] + H2O unmethylated oligonucleotide GpppG-16nt is hydrolyzed by the enzyme with greater efficiency than m7GpppG-16nt (86.9% hydrolysis after 180 min) Homo sapiens ?
-
 ?
GpppG-[34nt mRNA] + H2O 81.44% hydrolysis after 5 min Homo sapiens ?
-
 ?
m3-2.2.7GpppG + H2O 64.96% hydrolysis after 100 min Homo sapiens ?
-
 ?
m7GpppA + H2O 2.57% hydrolysis after 100 min Homo sapiens ?
-
 ?
m7GpppA-[16nt mRNA] + H2O 45.19% hydrolysis after 240 min Homo sapiens ?
-
 ?
m7GpppG + H2O 72.97% hydrolysis after 100 min Homo sapiens ?
-
 ?
m7GpppG-[16nt mRNA] + H2O 94.76% hydrolysis after 180 min Homo sapiens ?
-
 ?
m7GpppG-[34nt mRNA] + H2O 51.85% hydrolysis after 180 min Homo sapiens ?
-
 ?
m7Gpppm2'-OA + H2O 1.68% hydrolysis after 100 min Homo sapiens ?
-
 ?
m7Gpppm2'-OA-[16nt mRNA] + H2O 49.65% hydrolysis after 240 min Homo sapiens ?
-
 ?
m7Gpppm2'-OG + H2O 76.89% hydrolysis after 100 min Homo sapiens ?
-
 ?
m7Gpppm2'-OG-[16nt mRNA] + H2O 80.52% hydrolysis after 60 min Homo sapiens ?
-
 ?
m7Gpppm2'-OG-[34nt mRNA] + H2O 43.86% hydrolysis after 180 min Homo sapiens ?
-
 ?
additional information dinucleotide cap analogs and capped oligonucleotides containing guanine base in the first transcribed nucleotide are more susceptible to enzymatic digestion by the enzyme than their counterparts containing adenine Homo sapiens ?
-
-
additional information no hydrolysis of dinucleotide m7Gpppm7G after 100 min Homo sapiens ?
-
-
trimethylguanosine-[16nt mRNA] + H2O 82.62% hydrolysis after 60 min Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Nudt16
-
 Homo sapiens