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Literature summary for 3.6.1.62 extracted from

  • Li, Y.; Ho, E.S.; Gunderson, S.I.; Kiledjian, M.
    Mutational analysis of a Dcp2-binding element reveals general enhancement of decapping by 5'-end stem-loop structures (2009), Nucleic Acids Res., 37, 2227-2237.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
m7G5'ppp5'-mRNA + H2O Homo sapiens mRNA decapping is a critical step in the control of mRNA stability and gene expression m7GDP + 5'-phospho-mRNA
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
m7G5'ppp5'-mRNA + H2O mRNA decapping is a critical step in the control of mRNA stability and gene expression Homo sapiens m7GDP + 5'-phospho-mRNA
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m7G5'ppp5'-mRNA + H2O a 60 nucleotide element at the 5' end of the mRNA encoding Rrp41 is preferentially bound and decapped by Dcp2. Enhanced decapping of this element is dependent on the structural integrity of its first 33 nt and not its primary sequence. The structure consists of a stem-loop positioned <10 nt from the 5' end of the mRNA Homo sapiens m7GDP + 5'-phospho-mRNA
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General Information

General Information Comment Organism
physiological function mRNA decapping is a critical step in the control of mRNA stability and gene expression Homo sapiens