Ligand m7GDP

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Basic Ligand Information

Molecular Structure
Picture of m7GDP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H17N5O11P2
m7GDP
SBASPRRECYVBRF-KQYNXXCUSA-O
Synonyms:
7-methyl-GDP, 7-methylGDP, 7-methylguanosine(5')diphosphate, 7-methylguanosine 5'-diphosphate, 7-methylguanosine diphosphate, N7-methyl-GDP, N7-methylguanosine 5'-diphosphate, ppm7G

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7-methylguanosine 5'-diphosphate + H2O = 7-methylguanosine 5'-phosphate + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-triphospho-AACAG + 7-methylguanosine 5'-diphosphate = diphosphate + 7-methylguanosine 5'-triphospho-AACAG
show the reaction diagram
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7-methylguanosine diphosphate + H2O = 7-methylguanosine monophosphate + phosphate
show the reaction diagram
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N7-methyl-GDP + H2O = N7-methyl-guanosine + 2 phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + GDP = S-adenosyl-L-homocysteine + m7GDP
show the reaction diagram
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7-methyl-GTP + H2O = 7-methyl-GDP + phosphate
show the reaction diagram
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7-methyl-GTP + H2O + closed Cl- channel = 7-methyl-GDP + phosphate + open Cl- channel
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (36 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0017
-
pH 7.0, 30°C, Dcs1 homodimer

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00026
-
pH 7.0, 30°C, Dcs1 homodimer

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000038
-
at pH 7.5 and 30°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00039
-
at pH 7.5 and 30°C
0.3
-
pH 7.5, 37°C

References & Links

Links to other databases for m7GDP

ChEBI
PubChem
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PubChem