EC Number   |
General Information |
Reference |
|---|
   3.6.1.62 | malfunction |
enzyme-deficient viruses are attenuated in mice. Decapping-deficient vaccinia virus also potently reduces tumor growth in a human hepatocellular carcinoma xenograft model |
757710 |
| 3.6.1.62 | malfunction |
no obvious phenotypic difference or differences in fertility, life span, or litter size are detected between the wild type animals and Dcp2b/b mice (mice containing a homozygous insertion of the beta-geo gene as Dcp2beta/beta) |
716218 |
| 3.6.1.62 | malfunction |
null mutants of DCP1 accumulate capped mRNAs with a reduced degradation rate. Lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology |
716514 |
| 3.6.1.62 | malfunction |
reduction of enzyme protein levels in MCF-7 cells promotes increased cell migration and corresponding enhanced filopodia extensions. Enzyme depletion elevates RNA and protein expression of integrin beta6 and fibronectin, which in turn increases MCF-7 cell motility |
758325 |
| 3.6.1.62 | physiological function |
D9 is expressed early in infection and D10 late. It is suggested that the two proteins enhance mRNA turnover and manipulate gene expression in a complementary and overlapping manner |
716062 |
| 3.6.1.62 | physiological function |
embryonic fibroblast cells with reduced Dcp2 levels contain significantly elevated levels of mRNAs encoding proteins involved in the type I IFN response. Both IRF-7 mRNA and protein are increased in cells with reduced Dcp2 levels. The increase in IRF-7 mRNA within the background of reduced Dcp2 levels is attributed to a stabilization of the IRF-7 mRNA, suggesting that Dcp2 normally modulates IRF-7 mRNA stability |
734680 |
| 3.6.1.62 | physiological function |
many long noncoding RNAs degraded by DCP2 are expressed proximal to inducible genes. Of these, several genes required for galactose utilization are associated with long noncoding RNAs that have expression patterns inversely correlated with their mRNA counterpart. Decapping of these lncRNAs is critical for rapid and robust induction of GAL gene expression |
734687 |
| 3.6.1.62 | physiological function |
mRNA decapping is a critical step in the control of mRNA stability and gene expression |
716369 |
| 3.6.1.62 | physiological function |
Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs |
716218 |
| 3.6.1.62 | physiological function |
the enzyme is a modulator of MCF-7 breast cancer cell migration |
758325 |
