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Literature summary for 3.6.1.62 extracted from
- Multiple mRNA decapping enzymes in mammalian cells (2010), Mol. Cell., 40, 423-432.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| m7G5'ppp5'-mRNA + H2O | Homo sapiens | regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | m7GDP + 5'-phospho-mRNA | - |
? |  |
| m7G5'ppp5'-mRNA + H2O | Mus musculus | regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | m7GDP + 5'-phospho-mRNA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8IU60 | - |
- |
| Homo sapiens | Q96DE0 | - |
- |
| Mus musculus | Q6P3D0 | 4-week-old C57BL/6 mice | - |
| Mus musculus | Q9CYC6 | 4-week-old C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| brain | Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult | Mus musculus | - |
| brain | highest expression level. Dcp2 can be detected in the brain at all the developmental stages tested | Mus musculus | - |
| embryo | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| heart | Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult | Mus musculus | - |
| HEK-293 cell | - |
Homo sapiens | - |
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult | Mus musculus | - |
| liver | - |
Mus musculus | - |
| liver | Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult | Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | no activity in liver | Homo sapiens | - |
| ovary | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Mus musculus | - |
| testis | highest expression level | Mus musculus | - |
| thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| m7G5'ppp5'-mRNA + H2O | - |
Homo sapiens | m7GDP + 5'-phospho-mRNA | - |
? | |
| m7G5'ppp5'-mRNA + H2O | regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | Homo sapiens | m7GDP + 5'-phospho-mRNA | - |
? | |
| m7G5'ppp5'-mRNA + H2O | regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | Mus musculus | m7GDP + 5'-phospho-mRNA | - |
? | |
| m7G5'ppp5'-mRNA + H2O | Dcp2 can only function on capped RNA but not N7-methyl cap structure (m7GpppN) | Mus musculus | m7GDP + 5'-phospho-mRNA | - |
? | |
| m7G5'ppp5'-mRNA + H2O | Nudt16 can only function on capped RNA but not N7-methyl cap structure (m7GpppN) | Homo sapiens | m7GDP + 5'-phospho-mRNA | - |
? | |
| m7G5'ppp5'-mRNA + H2O | Nudt16 can only function on capped RNA but not N7-methyl cap structure (m7GpppN) | Mus musculus | m7GDP + 5'-phospho-mRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dcp2 | - |
Homo sapiens |
| Dcp2 | - |
Mus musculus |
| Nudt16 | - |
Homo sapiens |
| Nudt16 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | no obvious phenotypic difference or differences in fertility, life span, or litter size are detected between the wild type animals and Dcp2b/b mice (mice containing a homozygous insertion of the beta-geo gene as Dcp2beta/beta) | Mus musculus |
| physiological function | Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | Homo sapiens |
| physiological function | Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs | Mus musculus |
| physiological function | the presence or absence of detectable Dcp2 does not appreciably alter stability of the transfected RNA and suggests Dcp2 may not be involved in bulk mRNA decapping in cells. Dcp2 appears to be a minor contributor to mRNA stability and raises the intriguing possibility for the presence of a Dcp2-independent decapping activity in mammalian cells | Mus musculus |
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Release 2023.1 (January 2023)
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