Information on EC 3.4.17.24 - tubulin-glutamate carboxypeptidase

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The enzyme appears in viruses and cellular organisms
Reaction Schemes
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
Synonyms
AGBL5, CCP1, CCP5, CCPP-1, ccpp-6, cytosolic carboxypeptidase 1, cytosolic carboxypeptidase 5, cytosolic carboxypeptidase 6, cytosolic carboxypeptidase CCP1, cytosolic carboxypeptidase-like protein 5, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
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