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Literature summary for 3.4.17.24 extracted from

  • Berezniuk, I.; Vu, H.; Lyons, P.; Sironi, J.; Xiao, H.; Burd, B.; Setou, M.; Angeletti, R.; Ikegami, K.; Fricker, L.
    Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin (2012), J. Biol. Chem., 287, 6503-6517.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.24

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q09M02
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
detyrosinated alpha-tubulin + H2O porcine brain tubulin Homo sapiens DELTA2-tubulin + L-glutamate i.e. tubulin lacking two C-terminal amino acids ?
detyrosinated alpha-tubulin + H2O porcine brain tubulin Mus musculus DELTA2-tubulin + L-glutamate i.e. tubulin lacking two C-terminal amino acids ?
additional information isoform CCP1 removes Glu residues from the polyglutamyl side chains of porcine brain alpha- and beta-tubulin and also generates a form of alpha-tubulin with two C-terminal Glu residues removed Homo sapiens ?
-
 ?
additional information isoform CCP1 removes Glu residues from the polyglutamyl side chains of porcine brain alpha- and beta-tubulin and also generates a form of alpha-tubulin with two C-terminal Glu residues removed Mus musculus ?
-
 ?
polymerized microtubules + H2O
-
 Homo sapiens DELTA2-tubulin + ? i.e. tubulin lacking two C-terminal amino acids ?
polymerized microtubules + H2O
-
 Mus musculus DELTA2-tubulin + ? i.e. tubulin lacking two C-terminal amino acids ?

Synonyms

Synonyms Comment Organism
CCP1
-
 Mus musculus
cytosolic carboxypeptidase 1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function overexpression or knockdown (80–90%) of isoform CCP1 in human embryonic kidney 293T cells does not affect the levels of most intracellular peptides but alters the levels of alpha-tubulin lacking two C-terminal amino acids more than 5fold, suggesting that tubulin processing is the primary function of CCP1 Homo sapiens
physiological function the Purkinje cell degeneration (pcd) mouse has a disruption in the gene encoding cytosolic carboxypeptidase 1. Pcd mutant mouse brain shows hyperglutamylation of both alpha- and beta-tubulin Mus musculus